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Proteomics1 Structure of the peroxisomal retro-translocon formed by a heterotrimeric ubiquitin ligase 2 complex
Peroxisomes are ubiquitous organelles that house various metabolic reactions and are essential for human health. Luminal peroxisomal proteins are imported from the cytosol by mobile receptors, which then recycle back to the cytosol by a poorly understood process. Recycling requires receptor modifica...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-07-20 | PXD031792 | Pride
Polyubiquitination Tmtpro Peroxisomes Cryo-em Yeast 
ProteomicsA conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast
Organelles are shaped by curvature-generating proteins, which include the reticulons and REEPs that are involved in forming the endoplasmic reticulum (ER). A conserved REEP subfamily differs from the ER-shaping REEPs in abundance and membrane topology and has unidentified functions. Here, we show th...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-08-06 | PXD043260 | Pride
Reep1 Autophagy Fission yeast 
ProteomicsThe membrane curvature-inducing REEP1-4 proteins generate an ER-derived vesicular compartment
The endoplasmic reticulum (ER) is shaped by abundant membrane curvature-generating proteins that include the REEP family member REEP5. The REEP1 subfamily, consisting of REEP1-4 in mammals, is less abundant and lacks a N-terminal region. Mutations in REEP1 and REEP2 cause Hereditary Spastic Parapleg...
ORGANISM(S): Homo sapiens (Human) 
2025-01-18 | PXD055950 | Pride
Reep5 Reep1 Endoplasmic reticulum Membrane curvature Tubules Vesicles Hereditary spastic paraplegia 
ProteomicsProteomic analysis of peroxisome-associated PEX5 mutants in Xenopus egg extract.
This project sought to identify the features in PEX5 required for interaction with the peroxisomal PEX2-PEX10-PEX12 ubiquitin ligase complex. Peroxisomes equilibrated with different PEX5 mutants (i.e., C11A, AH1, AH2) were purified from Xenopus egg extract, solubilized in digitonin, and PEX5-associa...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-16 | PXD035105 | Pride
Peroxisome Pex5 
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