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GenomicsCircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis
CircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis
PRJNA1121955 | ENA
TranscriptomicsMEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors, despite transcriptional feedback onto ERK.
Neurofibromatosis Type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve tumors result from loss of NF1 tumor suppressor gene function, causing hyperactive Ras signaling. Activated Ras controls numerous downstream eff...
ORGANISM(S): Mus musculus 
2012-12-28 | E-GEOD-41747 | biostudies-arrayexpress
TranscriptomicsCircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis
Mutations in oncogenes such as KRAS, NRAS and BRAF promote cancer cell survival and proliferation, while excessive RAS/RAF/MEK/ERK signaling instead exerts an inhibitory effect on tumor growth. The precise regulatory mechanism of moderate RAS/RAF/MEK/ERK pathway activation during tumorigenesis remai...
ORGANISM(S): Homo sapiens 
2026-06-13 | GSE269456 | GEO
ProteomicsCharacterization, Antioxidant Effects of Lycium ruthenicum Murr. Polysaccharides and its Protective Effects Against Oxaliplatin-Induced Peripheral Neurotoxicity by Inhibiting the RAS-RAF-MEK-ERK Signaling Pathway
Oxaliplatin is a frequently used chemotherapeutic agent; however, oxaliplatin-induced peripheral neuropathy (OIPN) is a prevalent adverse effect for which no effective treatment currently exists. Lycium ruthenicum Murr. (LR), a traditional Chinese medicinal herb also consumed as food, is rich in pol...
ORGANISM(S): Rattus Norvegicus 
2025-11-26 | PXD071288 |
UnknownTargeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy.
Not available
S-EPMC7017232 | biostudies-literature
UnknownOnco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation.
Not available
S-EPMC9363660 | biostudies-literature
UnknownCircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis.
Not available
S-EPMC11369509 | biostudies-literature
UnknownTargeting RAS-RAF-MEK-ERK signaling pathway in human cancer: Current status in clinical trials.
Not available
S-EPMC10066287 | biostudies-literature
UnknownKinase suppressor of Ras 1 (KSR1) promotes liver carcinogenesis via activation of the RAS/RAF/MEK/ERK signaling pathway.
Not available
S-EPMC12509110 | biostudies-literature
UnknownPolymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer.
Not available
S-EPMC6356706 | biostudies-literature
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