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CircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis
Oxaliplatin is a frequently used chemotherapeutic agent; however, oxaliplatin-induced peripheral neuropathy (OIPN) is a prevalent adverse effect for which no effective treatment currently exists. Lycium ruthenicum Murr. (LR), a traditional Chinese medicinal herb also consumed as food, is rich in pol...
ORGANISM(S): Rattus Norvegicus 
2025-11-26 | PXD071288 |
Mutations in oncogenes such as KRAS, NRAS and BRAF promote cancer cell survival and proliferation, while excessive RAS/RAF/MEK/ERK signaling instead exerts an inhibitory effect on tumor growth. The precise regulatory mechanism of moderate RAS/RAF/MEK/ERK pathway activation during tumorigenesis remai...
ORGANISM(S): Homo sapiens 
2026-06-13 | GSE269456 | GEO
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