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TranscriptomicsmicroRNA sequencing in rat cardiac fibroblasts and fibroblast-derived exosomes
We found that cardiac fibroblasts produce and secrete exosomes. miRNA profiling and TaqMan qRT-PCR experiments identified miR-21 expression to be higher in cardiac fibroblasts compared to those of miR-21*, whereas in exosomes miR-21* expression was higher compared to miR-21. The purpose of the stud...
ORGANISM(S): Rattus norvegicus 
2015-12-19 | E-GEOD-76175 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat cardiac myocytes and fibroblasts subjected to 24 hours of mechanical stress, or treated with a single dose of ionizing or ultraviolet radiation and allowed to recover for 24 hours
Rationale: During excessive pressure or overload, cardiac cells are subjected to increased mechanical stress. We investigate how the stress response of cardiac cells to mechanical stress can be compared to genotoxic stresses induced by DNA damaging agents. Methods: Cultures enriched for cardiomyocyt...
ORGANISM(S): Rattus norvegicus 
2007-09-18 | E-GEOD-2032 | biostudies-arrayexpress
TranscriptomicsReversible and irreversible differentiation of cardiac fibroblasts
Aim: Differentiation of cardiac fibroblasts (Fb) into myofibroblasts (MyoFb) is responsible for connective tissue buildup in myocardial remodeling. We examined reversibility of MyoFb differentiation. Methods and Results: Adult rat cardiac Fb were cultured on a plastic substratum providing mechanical...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-51824 | biostudies-arrayexpress
ProteomicsProteomics of rat neonatal cardiac fibroblasts
Gβγ subunits are involved in many different signalling processes in various compartments of the cell, including the nucleus. To gain insight into the functions of nuclear Gβγ, we investigated the functional role of Gβγ signalling in regulation of GPCR-mediated gene expression in primary rat neonatal...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-10 | PXD025993 | Pride
Gnb1 Rat cardiac fibroblasts Angiotensin ii Bottom-up proteomics 
TranscriptomicsExpression data from rat cardiac fibroblasts
The overall data contains expression profile of rat genes of cardiac fibroblasts. G-protein signaling is regulated in cardiac fibroblasts. The expresssion of angiotensin II receptor or cytokine such as interleukin is regulated by PTX (which is suggested to suppress Gi function) treatment. Keywords: ...
ORGANISM(S): Rattus norvegicus 
2010-03-23 | E-GEOD-5017 | biostudies-arrayexpress
ProteomicsChitin-binding peptides from rat cardiac fibroblasts
Chitin-binding peptides from rat cardiac fibroblasts
ORGANISM(S): Cellular Organisms 
2023-12-26 | PXD039099 | JPOST Repository
TranscriptomicsProtective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling
1.1 Introduction Cardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is m...
ORGANISM(S): Homo sapiens 
2024-11-30 | E-MTAB-14602 | biostudies-arrayexpress
GenomicssiRNA knockdown of neonatal rat cardiac myocytes and fibroblasts
siRNA knockdown of neonatal rat cardiac myocytes and fibroblasts
PRJNA446648 | ENA
TranscriptomicsLeft ventricular myocardial transcriptomic profiling for target discovery in a rat model of pressure overload-induced heart failure
Left ventricular myocardial transcriptomic profiling was performed in rats subjected to transverse aortic constriction (TAC)-induced heart failure and sham-operated controls to investigate gene expression changes associated with pressure overload-induced cardiac remodeling. The dataset was used in s...
ORGANISM(S): Rattus norvegicus 
2026-06-11 | E-MTAB-17114 | biostudies-arrayexpress
GenomicsRNA-Seq of rat cardiac fibroblasts depleted for Yap and Wwtr1
RNA-Seq of rat cardiac fibroblasts depleted for Yap and Wwtr1
PRJNA768827 | ENA
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