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ProteomicsProteomic profiles of Rat Pancreatic Islets
In this study, we achieved integrated transcriptomic and proteomic profiles of GK islets in a time-course fashion at different stages of T2D. Subsequent bioinformatics analysis revealed the chronological order of T2D-related molecular events during the deterioration of pancreatic islets. Our large q...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-06-02 | PXD004709 | Pride
Rat islets proteome 
ProteomicsQuantitative proteomics of human pancreatic beta cells
Outline: using label-free alternate-scanning LC-MS/MS, we compared the proteomic architecture of core functional pathways in pancreatic beta cells of human origin. Results: we quantified the relative molar abundance of 707 proteins mainly composed of functional pathways of metabolism, protein synthe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-31 | MSV000082882 | MassIVE
ProteomicsRedox-proteomic analysis of pancreatic β-cells upon glucose stimulation
Redox signaling mediated by reversible oxidative cysteine thiol modifications is crucial for driving cellular adaptation to dynamic environmental changes, maintaining homeostasis, and ensuring proper function. This is particularly critical in pancreatic β-cells, which are highly metabolically active...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2024-09-30 | PXD052765 | Pride
Iodotmt Redox proteomics 
UnknownSecretome Analysis of Human and Rat Pancreatic Islets Co-Cultured with Adipose-Derived Stromal Cells Reveals a Signature with Enhanced Regenerative Capacities.
Not available
S-EPMC11854805 | biostudies-literature
UnknownImpact of exposure to low concentrations of nitric oxide on protein profile in murine and human pancreatic islet cells.
Not available
S-EPMC4398281 | biostudies-literature
ProteomicsFragmentation of mitochondrial mt-tRNA-LeuTAA provides a regulator of metabolic physiology
In this study, we discovered cytosolic and mitochondrial fragments resulting from tRNA and mt-tRNA cleavage, which may act as new regulators of cellular and metabolic functions. We selected the mt-tRF-LeuTAA fragment derived from a tRNA encoded by the mitochondrial genome for further investigation, ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-06-16 | PXD046117 | Pride
Mitochondrial metabolism Trna-derived fragment Insulin secretion Insulin sensitivity Mitochondrial trna 
UnknownEffect of IAPP on the proteome of cultured Rin-5F cells.
Not available
S-EPMC6233276 | biostudies-literature
UnknownSpatial- and Phospho-Proteomic Profiling Reveals Pancreatic and Hepatic Dysfunction in a Rat Model of Lethal Insulin Overdose.
Not available
S-EPMC12652034 | biostudies-literature
UnknownA possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets.
Not available
S-EPMC3919173 | biostudies-literature
ProteomicsSustained hyperglycemia specifically targets translation of mRNAs for insulin secretion
Pancreatic beta-cells are specialized for coupling glucose metabolism to insulin peptide production and secretion. Acute glucose exposure robustly and coordinately increases translation of proinsulin and proteins required for secretion of mature insulin peptide. By contrast, chronically elevated glu...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-03 | PXD047140 | Pride
Nascent proteomics Glucose toxicity Ribosome profiling Islets Mrna translation Pancreatic -cells 
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