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ProteomicsCharacterization of RBM10 interactome in unchallenged and MK1775-treated cells
Mapping of RBM10-interactome using GFP-trap purification of EGFP-RBM10 expressed in HEK293T cells before and after WEE1 inhibition by MK1775. HEK293T expressing EGFP only or EGFP-RBM10 fusion (2 main isoforms) were left untreated or treated with 300nM MK1775 for 4 hours prior to GFP-trap enrichment ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD040109 | Pride
Rbm10 wee1 mk1775 luad 
GenomicsCRISPR-Cas9 RBM10 synthetic lethality screen
Genome-wide CRISPR-Cas9 knockout screen using TKOv1 sgRNA library was performed in isogenic RBM10-proficient and RBM10-deficient HCC827 cells.
ORGANISM(S): Homo sapiens 
2023-03-04 | E-MTAB-12724 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of alternative splicing regulated by RBM10
RBM10 is an RNA binding protein that was identified as a component of spliceosome complex, suggesting its potential role in splicing regulation. However, the direct experimental evidence for this function has been lacking. Here we characterized in vivo RBM10-RNA interactions and investigated the rol...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-GEOD-44976 | biostudies-arrayexpress
TranscriptomicsRegulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation (CLIP-Seq)
RBM5, a regulator of alternative splicing of apoptotic genes, and its close homologues, RBM6 and RBM10, are RNA binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically regulate the proliferative capacity of cancer cells and display distinct pos...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-48066 | biostudies-arrayexpress
TranscriptomicsRegulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation
RBM5, a regulator of alternative splicing of apoptotic genes, and its close homologues, RBM6 and RBM10, are RNA binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically regulate the proliferative capacity of cancer cells and display distinct pos...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-47431 | biostudies-arrayexpress
GenomicsGenome-wide CRISPR-Cas9 screen in isogenic parental and RBM10-KO HCC827 cells
Genome-wide CRISPR-Cas9 knockout screen using TKOv1 sgRNA library performed in isogenic RBM10-proficient and RBM10-deficient HCC827 cells.
ORGANISM(S): Homo sapiens 
2024-03-01 | E-MTAB-13626 | biostudies-arrayexpress
TranscriptomicsRNA-seq of RBM10 in LUAD cell lines
RNA-seq in isogenic RBM10-proficient and RBM10-deficient cells derived from lung adenocarcinoma cell lines HCC827 (parental and RBM10 knockout; control siRNA and RBM10 siRNA) and NCI-H1299 (parental and RBM10 knockout).
ORGANISM(S): Homo sapiens 
2024-04-01 | E-MTAB-13617 | biostudies-arrayexpress
GenomicsCRISPR-Cas9 RBM10 synthetic lethality screen
CRISPR-Cas9 RBM10 synthetic lethality screen
PRJEB60386 | ENA
GenomicsRNA-seq of RBM10 in LUAD cell lines
RNA-seq of RBM10 in LUAD cell lines
PRJEB70950 | ENA
GenomicsIdentification of RBM5 and RBM10-dependent splicing events in 293Flp-In cells.
Identification of RBM5 and RBM10-dependent splicing events in 293Flp-In cells.
PRJNA1003056 | ENA
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