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ProteomicsCharacterization of RBM10 interactome in unchallenged and MK1775-treated cells
Mapping of RBM10-interactome using GFP-trap purification of EGFP-RBM10 expressed in HEK293T cells before and after WEE1 inhibition by MK1775. HEK293T expressing EGFP only or EGFP-RBM10 fusion (2 main isoforms) were left untreated or treated with 300nM MK1775 for 4 hours prior to GFP-trap enrichment ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD040109 | Pride
Rbm10 wee1 mk1775 luad 
UnknownCombination of lutetium-177 labelled anti-L1CAM antibody chCE7 with the clinically relevant protein kinase inhibitor MK1775: a novel combination against human ovarian carcinoma.
Not available
S-EPMC6156869 | biostudies-literature
UnknownWee1 inhibitor MK1775 sensitizes KRAS mutated NSCLC cells to sorafenib.
Not available
S-EPMC5772438 | biostudies-literature
TranscriptomicsEffects of AKT/WEE1 inhibitors or ALDH inhibitor combined with PD-1 antibody on melanoma
The effects of AKT/WEE1 inhibitors or ALDH inhibitor combined with PD-1 antibody on melanoma were examined. Mouse B16F10 melanoma cells were subcutaneously injected into C57/B6 mice. When tumors were well-vascularized, mice were treated with anti-PD-1, AKT I (AZD5363)+WEE1 I (MK1775), AZD5363+MK1775...
ORGANISM(S): Mus musculus 
2023-12-31 | GSE199096 | GEO
GenomicsA nanounit strategy enhance Wee1 targeting potential by promoting ferroptosis sensitivity [II]
A nanounit strategy enhance Wee1 targeting potential by promoting ferroptosis sensitivity [II]
PRJNA901152 | ENA
UnknownHarnessing lipid metabolism modulation for improved immunotherapy outcomes in lung adenocarcinoma.
Not available
S-EPMC11256034 | biostudies-literature
UnknownRNAi screening of the kinome with cytarabine in leukemias.
Not available
S-EPMC8221104 | biostudies-literature
UnknownTargeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells.
Not available
S-EPMC8501558 | biostudies-literature
UnknownIdentification of therapeutic targets applicable to clinical strategies in ovarian cancer.
Not available
S-EPMC4997769 | biostudies-literature
GenomicsEffects of AKT/WEE1 inhibitors or ALDH inhibitor combined with PD-1 antibody on melanoma
Effects of AKT/WEE1 inhibitors or ALDH inhibitor combined with PD-1 antibody on melanoma
PRJNA818337 | ENA
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