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TranscriptomicsRBM20 orchestrates cardiac pre-mRNA
The RNA-binding protein RBM20 has been implicated in dilated cardiomyopathy (DCM), a major cause of chronic heart failure. To determine how RBM20 regulates alternative splicing, we combined transcriptome-wide CLIP-seq, RNA-seq, and quantitative proteomics in cell culture, rat, and human hearts. Our ...
ORGANISM(S): Homo sapiens 
2014-11-11 | E-MTAB-2572 | biostudies-arrayexpress
ProteomicsGlobal bottom-up analysis of wild type and RBM20 knock out rat hearts by LC-TIMS-MSMS
Dilated cardiomyopathy (DCM) is a major risk factor for developing heart failure and is often associated with an increased risk for life-threatening arrhythmia. Although numerous causal genes for DCM have been identified, RNA binding motif 20 (RBM20) remains one of the few splicing factors that, whe...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-12 | PXD033429 | Pride
Rat Rbm20 Heart Timstof pro 
ProteomicsMislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3
Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich domain (RS-domain). Such mutations can cause defective splicing and cytoplasmic mislocalization, which leads to the for...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD038790 | Pride
Human Heart Splicing Dilated cardiomyopathy 
ProteomicsInsights into differences in the dilated cardiomyopathy phenotype in mice carrying NLS variants in RBM20 revealed by multiomics
Global bottom-up proteomics analysis of WT and RBM20 KI variants (Rbm20 S637A and Rbm20 S639G) to establish proteomic differences.
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD051251 | Pride
Heart Mouse Rbm20 Dilated cardiomyopathy 
GenomicsRBM20 orchestrates cardiac pre-mRNA
RBM20 orchestrates cardiac pre-mRNA
PRJEB7700 | ENA
GenomicsSex differences in RBM20 cardiomyopathy
Sex differences in RBM20 cardiomyopathy
PRJNA892331 | ENA
TranscriptomicsHeart RNA-seq of control mice and mice with titin PEVK domain knockout, Rbm20 RNA recognition motif knockout, or double knockout
We report the heart RNA-sequencing of control animals (129S6 genetic background, wild type). Animal models comprise of Titin PEVK homozygous deletion of exons 219-225 (PEVK-KO), RBM20 heterozygous deletion of exons 6-7 (RBM20-HET), and double deletion (PEVK-KOxRBM20-HET). RNA from left ventricula...
ORGANISM(S): Mus musculus 
2023-11-30 | E-MTAB-11124 | biostudies-arrayexpress
TranscriptomicsHeart RNA-seq of control mice and a mouse model of cardiometabolic heart failure (HFpEF) treated with Rbm20 antisense oligonucleotides
We report the heart RNA-sequencing of control animals (C57BL/6N genetic background, wild type) and animals of a mouse model of cardiometabolic heart failure (HFpEF) treated or not with RBM20 antisense oligonucleotide. HFpEF was induced using a 2-hit regimen, in which male mice were fed with a high-f...
ORGANISM(S): Mus musculus 
2026-03-19 | E-MTAB-14882 | biostudies-arrayexpress
ProteomicsQuantitative RNA interactome capture (qRIC) identifies phosphorylation sites with regulatory potential - RBM20 BioID
RNA binding proteins (RBPs) are major regulators of gene expression at the post-transcriptional level. While many posttranslational modification sites in RBPs have been identified, less is known about how these modifications regulate RBP function. Here, we develop quantitative RNA-interactome captur...
ORGANISM(S): Homo sapiens (Human) 
2022-09-05 | PXD027138 | Pride
Lc-msms Rbm20 Silac Bioid 
GenomicsEffect of CAMK2D inhibition in RBM20 loss of function mouse models
Effect of CAMK2D inhibition in RBM20 loss of function mouse models
PRJNA1369419 | ENA
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