Sort   by:  
 Page size 
Proteomicsproteomics profiling of early retina degeneration of RCS rats
We employed proteomics analysis approach for in-depth retinal protein profiling of dystrophic RCS rats and non-dystrophic congenic controls through LTQ-orbitrap MS. We aim to identify the key molecular pathways and transcript factors involved in early retinal degeneration by differential proteomics ...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-07-24 | PXD004094 | Pride
Rcs rat Lc-ms Orbitrap Retinitis pigmentosa Retina 
TranscriptomicsGene expression changes in the retina following human neural progenitor cell injection into a rodent model for retinal degeneration
The goal of this study is to compare gene expression changes in retinal degenerate Royal College of Surgeons (RCS) rats following an injection of human neural progenitor cells (hNPCs) using RNA-seq, as compared to RCS rats receiving a sham surgery and wild-type Long Evans rats. These changes may lea...
ORGANISM(S): Rattus norvegicus 
2016-05-16 | E-GEOD-70600 | biostudies-arrayexpress
GenomicsThe transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis (ChIP-Seq)
SOX9 is a transcriptional activator required for chondrogenesis, and SOX5 and SOX6 are closely related DNA-binding proteins that critically enhance its function. We used RNA-seq to charatierize a rat chondrosarcoma (RCS) cells as a faithful model for proliferating/early prehypertrophic growth plate ...
ORGANISM(S): Rattus norvegicus 
2015-06-23 | E-GEOD-70143 | biostudies-arrayexpress
GenomicsRetinal gene expression changes from post-natal 21 (p21) to p60 during retinal degeneration in RCS rat.
Retinal gene expression changes from post-natal 21 (p21) to p60 during retinal degeneration in RCS rat.
PRJNA996639 | ENA
GenomicsInvestigation of the impact of Arylsulfatase L (ARSL) deletion in rat chondrosarcoma (RCS) cell lines
Investigation of the impact of Arylsulfatase L (ARSL) deletion in rat chondrosarcoma (RCS) cell lines
PRJNA1287369 | ENA
TranscriptomicsRetinal vessel microarray
We sought to identify differentially expressed genes in several animal models of a retinal disease exhibiting vascular abnormalities and/or angiogenesis compared to control animals. Retinal microvessels were isolated from three models (RD1, Grhl3ct (Curlytail), VLDLR knock-out) and one rat model (R...
ORGANISM(S): Rattus norvegicus 
2013-09-13 | E-MEXP-3323 | biostudies-arrayexpress
TranscriptomicsRetinal gene expression changes from post-natal 21 (p21) to p60 during retinal degeneration in RCS rat.
Molecular mechanisms underlying retinal degeneration are not well characterized including in the widely utilized Royal College of Surgeons (RCS) rat model of retinal degeneration. To better understand molecular pathways driving retinal degeneration we performed mRNA transcriptomics on RCS retinas fo...
ORGANISM(S): Rattus norvegicus 
2024-02-28 | GSE237804 | GEO
TranscriptomicsInvestigation of the impact of Arylsulfatase L (ARSL) deletion in rat chondrosarcoma (RCS) cell lines
In this study, we identified arylsulfatase L (ARSL), which is mutated in X-linked chondrodysplasia punctata (CDPX), as a Golgi-localized enzyme responsible for glycosaminoglycan (GAG) desulfation. To elucidate the cellular and molecular consequences of ARSL deficiency, we performed trasncriptome pro...
ORGANISM(S): Rattus norvegicus 
2026-08-04 | GSE301703 | GEO
UnknownIntraretinal Electrophysiology and Resistivity Profiles of WT and RCS Rat Retina.
Not available
S-EPMC12197074 | biostudies-literature
TranscriptomicsSalmonella typhimurium igaA(T191P) and related
We have exploited a spontaneously isolated mutant IgaA(T191P) that is near-maximally activated for the Rcs system, to identify a vast set of genes that respond, and report new regulatory properties of this signaling system in Salmonella enterica serovar Typhimurium. Microarray data show that the Rcs...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2008-06-24 | E-GEOD-9584 | biostudies-arrayexpress
Sort   by:  
 Page size