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TranscriptomicsRNA-Seq of wild-type HEK293 and K562 celllines
RNA-Seq was carried out in order to obtain the expression profile of Solute Carrier Family (SLC) of proteins in two commonly used celllines. We were specifically interested in the subset of SLCs that are capable of transporting amino acids.
ORGANISM(S): Homo sapiens 
2015-01-07 | E-MTAB-3102 | biostudies-arrayexpress
ProteomicsFull proteome analysis of Hoxb8 immortalized murine myeloid progenitors knockout for CCDC134 and differentiated into macrophages
We recently identified CCDC134 as a novel regulator of TLR responses. To gain a comprehensive understanding of the effects of CCDC134 loss, we conducted total proteome analysis on control sgRen and sgCCDC134 Hoxb8 immortalized murine myeloid progenitors that were differentiated into macrophages. Int...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-14 | PXD053042 | Pride
Ccdc134 Full proteome Hoxb8 macrophages 
ProteomicsIdentification of potential CCDC134 interactors by immunoprecipitation and LC-MS analysis
Our data indicate that CCDC134 plays a critical role in regulating the biogenesis of Toll-like receptors (TLRs). To gain deeper insights into the molecular mechanisms through which CCDC134 mediates TLR regulation, we sought to identify potential binding partners using interaction proteomics. Mass sp...
ORGANISM(S): Homo sapiens (Human) 
2024-11-14 | PXD053008 | Pride
Ccdc134 Immunoprecipitation Cal-1 
ProteomicsSLC15A4 (PHT1) interaction proteomics
Human genetics and mouse models provide compelling evidence for the involvement of SLC15A4 in endosomal TLR activation. To gain an understanding of the molecular mechanism, we set out to identify its binding partners by interaction proteomics. TAP-MS/MS analysis of different SLC15A4 protein variants...
ORGANISM(S): Homo sapiens (Human) 
2020-05-14 | PXD014254 | Pride
Human Slc Tap Cxorf21 Lc-ms/ms 
UnknownBrain Morphometry Estimation: From Hours to Seconds Using Deep Learning.
Not available
S-EPMC7156625 | biostudies-literature
UnknownDirect cortical thickness estimation using deep learning-based anatomy segmentation and cortex parcellation.
Not available
S-EPMC7643371 | biostudies-literature
UnknownDivide and Conquer: Stratifying Training Data by Tumor Grade Improves Deep Learning-Based Brain Tumor Segmentation.
Not available
S-EPMC6848279 | biostudies-literature
MetabolomicsGain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SL...

2022-09-20 | MTBLS4268 | MetaboLights
UnknownHippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction.
Not available
S-EPMC9668627 | biostudies-literature
UnknownA substrate-based ontology for human solute carriers.
Not available
S-EPMC7374931 | biostudies-literature
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