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ProteomicsGlycoproteomics profiling of recombinant SARS-CoV-2 stabilized Spike construct
N-linked glycans of recombinant SARS-CoV-2 Spike protein with stabilizing mutations were profiled by LC-MS/MS.
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2021-07-28 | PXD025554 | Pride
Sars-cov-2 Glycoproteomics Covid-19 
ProteomicsCross-linking mass spectrometry uncovers interactions between high-density lipoproteins and the SARS-CoV-2 spike glycoprotein
Multiple studies to date have shown that high-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and that the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key role during the lifecycle of he...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036640 | Pride
Xlms Covid Spike Sars-cov-2 Hdl 
ProteomicsSARS-CoV-2 spike protein glycosylation enriched by HILIC and Ti-IMAC
In this work, we performed a fully descriptive analysis N- and O- linked glycosylation of SARS-COV-2 S glycoprotein. We investigated that dual-functionalized Ti-IMAC material enable the simultaneous enrichment and separation of neutral and sialyl glycopeptides of a recombinant SARS-CoV-2 S glycoprot...
ORGANISM(S): Homo sapiens (Human) 
2022-01-11 | PXD026450 | Pride
Sars-cov-2 Spike protein 
ProteomicsA Linkage- Specific Sialic Acid Labeling Strategy Reveals Different Site-Specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus utilizes an extensively glycosylated spike protein that protrudes from the viral envelope to bind to angiotensin-converting enzyme-related carboxypeptidase (ACE2) as its primary receptor to mediate host-cell entry. Currently, the...
ORGANISM(S): Homo sapiens (Human) Cricetulus barabensis 
2022-02-17 | PXD027536 | Pride
Lc-msms Glycopeptide Recombinant sars-2 spike Sialic acids labeling 
ProteomicsSite-specific glycosylation patterns of SARS-CoV-2 spike derived from recombinant protein and viral WA1 and D614G strains
We have characterized the site-specific glycosylation patterns of the HEK293 recombinant spike RBD and S1 domains as well as the intact spike derived from whole virus produced in Vero cells.
ORGANISM(S): Homo sapiens (Human) Cercopithecus aethiops (Green monkey) (Grivet) 
2022-02-16 | PXD029218 | Pride
Wa1 and d614g Sars-cov-2 Glycosylation 
ProteomicsCross-linking mass spectrometry uncovers interactions between high-density lipoproteins and the SARS-CoV-2 spike glycoprotein
Multiple studies to date have shown that high-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and that the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key role during the lifecycle of he...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD042625 | Pride
Hdl Spike Xlms. cov 
ProteomicsSite-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins using High-Resolution Mass Spectrometry
The global pandemic of severe acute pneumonia syndrome (COVID-19) caused by SARS-CoV-2 urgently calls for prevention and intervention strategies. The densely glycosylated spike (S) protein highly exposed on the viral surface is a determinant for virus binding and invasion into host cells as well as ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-05 | PXD018506 | Pride
Sars-cov-2  spike protein  n-glycosylation  mass spectrometry 
ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-09-12 | PXD027279 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-02-12 | PXD027425 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
ProteomicsImpact of mutations on the plant-based production of recombinant SARS-CoV-2 RBD
Recombinant RBD variants from SARS-CoV-2 spike were produced by transient expression in Nicotiana benthamiana plants and purified. The purified proteins were digested with proteases and glycopeptides were analysed by MS to identify the N-glycan structures.
ORGANISM(S): Nicotiana benthamiana 
2024-01-26 | PXD044462 | Pride
Glycosylation Virus Glycoprotein Vaccine Antigen Nicotiana benthamiana Spike protein 
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