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MetabolomicsRectal-content metabolomic profiling of periparturient dairy cows supplemented with high-dose chromium propionate before calving
This study contains untargeted LC-MS/MS metabolomic profiles of rectal-content samples collected on the day of calving from Holstein dairy cows in the control and high-dose chromium propionate supplementation groups. Cows received either a basal total mixed ration without supplemental chromium propi...
2026-09-26 | MTBLS15543 | MetaboLights
MetabolomicsUntargeted Metabolomics Data of Rectal Contents from Diarrheic and Healthy Saanen Dairy Goats (MS (MTBLS))
This dataset aims to investigate alterations in intestinal metabolites associated with diarrhea in Saanen dairy goats. A total of 14 goats reared under the same intensive housing conditions were selected, including 7 healthy individuals and 7 diarrheic individuals. Diarrhea was defined based on clin...
2026-08-05 | MTBLS14666 | MetaboLights
MetabolomicsMetabolomics-based and functional validation to explore the effect of the gut microbe-associated metabolite guanidinoacetic acid on rectal adenocarcinoma

Objective: The gut microbiota plays a crucial role in rectal adenocarcinoma (READ). Nonetheless, little is known about corresponding changes in gut microbiota–host interactions. This study aimed to identify the structure of the gut microbiota and the characteristics of faecal metabolites in patie...

2025-06-29 | MTBLS12620 | MetaboLights
MetabolomicsMicrobiome and metabolome patterns centered on cancer cachexia link skeletal muscle and adipose tissue depletion to clinical outcomes in locally advanced rectal cancer

This study employed untargeted serum metabolomics to delineate the specific metabolic landscape of cancer cachexia in patients with locally advanced rectal cancer. By analyzing LC-MS raw data from 133 patients (64 discovery, 69 validation), we identified and validated key cachexia-associated meta...

2026-05-09 | MTBLS13787 | MetaboLights
TranscriptomicsThe rectal cancer microRNAome - a comprehensive comparative analysis of microRNA expression in rectal cancer and matched normal mucosa
Purpose: MicroRNAs play a prominent role in a variety of physiological and pathological biological processes, including cancer. For rectal cancers, only limited data are available on microRNA expression profiles, while the underlying genomic and transcriptomic aberrations have been firmly establishe...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-38389 | biostudies-arrayexpress
TranscriptomicsKinase activity profiling of human locally advanced rectal cancer samples
Locally advanced rectal cancer characterized by multiplex kinase activity profiling
ORGANISM(S): Homo sapiens 
2010-08-05 | E-TABM-913 | biostudies-arrayexpress
MetabolomicsRectal microbiomes and serum metabolomics reveal changes in serum antioxidant status and immune responses of Dezhou donkeys in late gestation to parturition

Background: Parturition is a critical event in the reproductive cycle of dairy animals, accompanied by multiple physiological changes in sex hormones, metabolism, antioxidant capacity and immune function. However, the changes in the rectal microbiota and metabolic products of Jennies from late ge...

2025-08-27 | MTBLS12897 | MetaboLights
TranscriptomicsA specific miRNA signature correlates with complete pathological response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer
Background: MicroRNAs (miRNAs) are small, non-coding, RNA molecules which regulate numerous cellular processes. Specific miRNA may be abnormally down-regulated or up-regulated in colorectal cancer and have been found associated with prognosis or response to treatments. However, no study has ever ad...
ORGANISM(S): Homo sapiens 
2012-04-24 | E-GEOD-29298 | biostudies-arrayexpress
TranscriptomicsIntegrating chromosomal aberrations and gene expression profiles to dissect rectal cancer
Accurate staging of rectal tumors is essential for making the correct treatment choice. In a previous study, we found that loss of 17p, 18q and gain of 8q, 13q and 20q could distinguish adenoma from carcinoma tissue and that loss of 1q was related to lymph node metastasis. In order to find markers f...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12225 | biostudies-arrayexpress
TranscriptomicsGenotyping of human chromosomal instability patterns discriminates rectal adenomas from carcinomas
Total mesorectal excision (TME) is the standard treatment for rectal cancer, while transanal endoscopic microsurgery (TEM) is a recently introduced surgical approach for the treatment of rectal adenomas. Incorrect preoperative staging before TEM is a problem. To identify genetic changes that migh...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-7946 | biostudies-arrayexpress
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