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Proteomicsstudy of actin interactome in Alzheimers disease mouse model
Filamentous actin (F-actin) is one of the major cytoskeleton proteins present in dendritic spines and it is an essential component for defining dendritic spine morphology. We have shown that synaptosomal F-actin levels were significantly decreased in APP/PS1 mice as early as one month of age. The mo...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050802 | Pride
F-actin loss Alzheimers disease Synapse 
TranscriptomicsHuman shSIRT6 TNF-alpha timecourse
We established HeLa cell lines stably expressing a short hairpin RNA against SIRT6 (S6 sh2), and then completed genome-wide microarray analysis in shSIRT6 knock-down and control pSR HeLa cells. Prior to RNA extraction, HeLa cells were treated with TNF-alpha (5 ng/ml) for the indicated times. Total R...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13206 | biostudies-arrayexpress
UnknownUncovering of natural allelic variants of key yield contributing genes by targeted resequencing in rice (Oryza sativa L.).
Not available
S-EPMC6547710 | biostudies-literature
GenomicsCircadian cycling of genome-wide histone methylation
Daily (circadian) clocks are essential for regulating and coordinating physiology in mammals. Modulation of local chromatin structure has been shown for only a small number of genes, principally thought to be directly modulated by Clock-mediated histone acetylation. Here we show that genome-wide cha...
ORGANISM(S): Mus musculus 
2013-01-08 | E-GEOD-23550 | biostudies-arrayexpress
UnknownPhase I Dose Volume Escalation of Rectally Administered PC-1005 to Assess Safety, Pharmacokinetics, and Antiviral Pharmacodynamics as a Multipurpose Prevention Technology (MTN-037).
Not available
S-EPMC11733313 | biostudies-literature
UnknownPreeclampsia at delivery is associated with lower serum vitamin D and higher antiangiogenic factors: a case control study.
Not available
S-EPMC8734360 | biostudies-literature
UnknownSafety and Phosphate-Binding Capacity of Oxylanthanum Carbonate in Healthy Volunteers.
Not available
S-EPMC11672196 | biostudies-literature
UnknownAdvancing the Field of Deimplementation: Perspectives on Low-Value Clinical Preventive Services.
Not available
S-EPMC12445723 | biostudies-literature
UnknownTreatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function.
Not available
S-EPMC3023557 | biostudies-literature
UnknownIntravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure.
Not available
S-EPMC3189485 | biostudies-literature
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