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MetabolomicsRedox proteomics reveal a role for peroxiredoxinylation in stress protection.

The redox state of proteins is essential for their function and guarantees cell fitness. Peroxiredoxins protect cells against oxidative stress, maintain redox homeostasis, act as chaperones, and transmit hydrogen peroxide signals to redox regulators. Despite the profound structural and functional...

2025-07-17 | MTBLS11979 | MetaboLights
MetabolomicsMetabolomics Analysis Identifies Glutamic acid and Cystine imbalances in COVID-19 Patients Without Comorbid Conditions. Implications on Redox Homeostasis and COVID-19 Pathophysiology

It is well known that the presence of comorbidities and age-related health issues may hide biochemical and metabolic features triggered by SARS-CoV-2 infection and other diseases associated to hypoxia, as they are by themselves chronic inflammatory conditions that may potentially disturb metaboli...

2024-08-26 | MTBLS5011 | MetaboLights
ProteomicsSpecificity and dynamics of H2O2 detoxification by the cytosolic redox regulatory network as revealed by in vitro reconstitution
The thiol redox state is a decisive functional characteristic of proteins in cell biology. Plasmatic cell compartments maintain a thiol-based redox regulatory network linked to the glutathione/glutathione disulfide couple (GSH/GSSG) and the NAD(P)H system. The basic network constituents are known an...
ORGANISM(S): Escherichia Coli 
2025-01-21 | PXD048374 | JPOST Repository
ProteomicsQuantitative analysis of redox proteome reveals protein thiol switches regulating fundamental processes in developmental hematopoiesis
Fetal and adult hematopoietic stem and progenitor cells (HSPCs) are characterized by distinct redox homeostasis that may influence their differential cellular behaviour in normal and malignant haematopoiesis. In this work, we have applied a quantitative mass spectrometry-based redox proteomic approa...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033115 | Pride
Oxidative modifications Oxidative stress Redox proteomics Hydrogen peroxide Human embryonic stem cells 
ProteomicsRedox-proteomic analysis of pancreatic β-cells upon glucose stimulation
Redox signaling mediated by reversible oxidative cysteine thiol modifications is crucial for driving cellular adaptation to dynamic environmental changes, maintaining homeostasis, and ensuring proper function. This is particularly critical in pancreatic β-cells, which are highly metabolically active...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2024-09-30 | PXD052765 | Pride
Iodotmt Redox proteomics 
ProteomicsRedox proteome analysis identifies reversible oxidized proteins in retinoic acid differentiated SH-SY5Y cells
Retinoic acid stimulated SH-SY5Y cells are a common model system to study the initial phases of neuronal differentiation. Although these processes are associated with redox-sensitive processes, no comprehensive analysis of oxidative modified cysteines, as one of the main targets for reactive oxygen ...
ORGANISM(S): Homo sapiens (Human) 
2020-03-30 | PXD014381 | Pride
Dynamics Neuronal differentiation Redox Redox proteomics 
ProteomicsGlobal redox proteome and phosphoproteome analysis reveals novel mode of Akt regulation
A major knowledge gap in cell signalling is defining the crosstalk between multiple types of post-translational modification (PTM). Here, we take a multi-omic approach (redox proteome, phosphoproteome and total proteome) to delineate signalling networks in adipocytes modulated by reactive oxygen spe...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-12-10 | PXD011525 | Pride
Phosphoproteome Akt Crosstalk Redox proteome 
Unknown50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis.
Not available
S-EPMC10618833 | biostudies-literature
UnknownComparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processes.
Not available
S-EPMC3234660 | biostudies-literature
UnknownIdentification of sulfhydryl-containing proteins and further evaluation of the selenium-tagged redox homeostasis-regulating proteins.
Not available
S-EPMC10755098 | biostudies-literature
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