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ProteomicsAlteration of DAMPs and regulated cell death under hyperlipidemic stress
We hypothesize that DAMPs and non-apoptotic regulated cell death processes are critical players of artery plaque progression with inadequate response to lipid-lowering treatment. Using high performant LC-MS/MS proteomic analysis we aim to uncover the silent mechanisms that govern the existing residu...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2022-02-22 | PXD026379 | Pride
Regulated cell death Proteomics Mass spectrometry Damps 
TranscriptomicsWithaferin A (WA) causes cell death in prostate cells.
Withaferin A (WA), a major chemical component of an Indian herb Withania somnifera, induces cell death (apoptosis/necrosis) in a variety of tumor cells, but its molecular mechanism remains elusive. We report that WA induces cell death selectively in high-grade prostate (PC-3 and DU-145) and tongue (...
ORGANISM(S): Homo sapiens 
2015-08-02 | E-GEOD-55728 | biostudies-arrayexpress
MetabolomicsA metabolite roadmap of the wood-forming tissue in Populus tremula (UPLC-MS assay; Wood fibre and ray cell tissue)

Wood, or secondary xylem, is the product of xylogenesis, a developmental process that begins with the proliferation of cambial derivatives and ends with mature xylem fibers and vessels with lignified secondary cell walls. Fully mature xylem has undergone a series of cellular processes, including ...

2020-09-01 | MTBLS1831 | MetaboLights
UnknownCharacterization of regulated cancer cell death pathways induced by the different modalities of non-thermal plasma treatment.
Not available
S-EPMC11442809 | biostudies-literature
ProteomicsExtracellular peptide Kratos restricts cell death during vascular development and stress in Arabidopsis
During plant vascular development, xylem tracheary elements (TEs) form water conducting, empty pipes through genetically regulated cell death. Cell death is prevented from spreading to non-TEs by unidentified intercellular mechanisms, downstream of METACASPASE9 (MC9)-mediated regulation of autophagy...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-01-31 | PXD010886 | Pride
Arabidopsis Vascular development Tracheary element Peptidomics Extracellular Cell death Metacaspase9 
UnknownAndrogens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells.
Not available
S-EPMC3032338 | biostudies-literature
TranscriptomicsGlobal transcriptomic profiling of lactacystin-mediated neuronal death
Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as ParkinsonM-bM-^@M-^Ys disease and AlzheimerM-bM-^@M-^Ys disease. Pharmacological proteasomal inhibitors such as lactacystin can induce apoptosis in cultured mouse co...
ORGANISM(S): Mus musculus 
2012-01-03 | E-GEOD-22465 | biostudies-arrayexpress
TranscriptomicsChloroplast-dependent programmed cell death is activated in Arabidopsis cell cultures after singlet oxygen production by Rose Bengal
Arabidopsis thaliana cell suspension cultures (ACSC) were subjected to 30-min, mild chemical treatments with three different singlet oxygen elicitors at low-medium light conditions (150 µE m–2 s–1) with the aim of getting a better understanding of singlet oxygen-mediated defence responses in plants....
ORGANISM(S): Arabidopsis thaliana 
2014-03-13 | E-GEOD-43551 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rice cells reveal bacterial lipopolysaccharides induce defense responses associated with programmed cell death
PAMP (Pathogen-Associated Molecular Pattern) recognition plays an important role in innate immune responses both in plants and animals. Lipopolysaccharides (LPS) of gram-negative bacteria are a typical PAMP molecule and have been reported to induce defense-related responses such as suppression of hy...
ORGANISM(S): Oryza sativa 
2008-11-06 | E-GEOD-5906 | biostudies-arrayexpress
TranscriptomicsPKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells
A variety of airborne pathogens can induce inflammatory responses in airway epithelial cells, which is a crucial component of host defence. However, excessive inflammatory responses and chronic inflammation also contribute to different diseases in the respiratory system. We hypothesized that the ac...
ORGANISM(S): Homo sapiens 
2013-05-27 | E-GEOD-44747 | biostudies-arrayexpress
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