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ProteomicsAKT isoform specific signaling
Phosphoproteome analysis of HL-1 cardiomyocytes carrying AKT1 or AKT2 isoform specific knock down, respectively. Six biological replicates were analysed. Cells were grown until reaching 90 % confluency, starved for 50 minutes followed by stimulation with 200 nM insulin for 10 minutes. In solution st...
ORGANISM(S): Mus musculus (Mouse) 
2014-08-28 | PXD000268 | Pride
Ltq-orbitrap Phosphoproteome Akt Hl-1 cardiac myocytes 
TranscriptomicsMixed-polarization phenotype of ascites-associated macrophagesin human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse
Ascites-associated macrophages were collected from human ovarian carcinoma patients and their expression profiles determined via Agilent microarrays. In addition, monocyte derived macrophages from healthy donors were differentiated ex-vivo with MCSF and GMCSF and their expression profiles determined...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-MTAB-1661 | biostudies-arrayexpress
OtherAKT1 AND AKT2 INDUCE DISTINCT PHOSPHORYLATION PATTERNS IN HL-1 CARDIAC MYOCYTES.
Data from ProteomeXchange, PXD ID: PXD000268. Experiment: DML2, file: folder summary. Published as part of J Proteome Res. 2014 Aug 27 . From the Abstract: {{i}} ... To gain more insight into AKT isoform specific signaling at the molecular level we investigated the phosphoproteome of HL-1 cardiomyo...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310003337 | GPMDB
Resource Reanalysis 
ProteomicsSecretome of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD028855 | Pride
Lyn kinase Hs-5 Stroma Bmsc Secretome Multi-omics 
ProteomicsProteome / pYome of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD030582 | Pride
Lyn kinase Hs-5 Stroma Bmsc Secretome Multi-omics 
TranscriptomicsChIPseq of PPARbeta/delta in MDA-MB-231luc cells
Chromatin-immunoprecipitated with antiPPARD and antiRXR antibodies was performed in MDA-MB-231luc1 cells.
ORGANISM(S): Homo_sapiens 
2013-02-26 | E-MTAB-1097 | biostudies-arrayexpress
TranscriptomicsExpression profiling, MDA-MB-231-luc2 response to GW501516
MDA-MB-231-luc2 cells were treated with the PPARd specific agonist GW501516 and the resulting expression changes profiled.
ORGANISM(S): Homo_sapiens 
2013-06-25 | E-MTAB-1262 | biostudies-arrayexpress
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