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ProteomicsNovel Eph receptor tyrosine kinase inhibitors block colorectal cancer cell growth
Despite advances, treatment of unresectable colorectal cancer remains a clinical challenge and the incidence of this malignancy is increasing in individuals below the age of fifty. Integrated genomic, transcriptomic, proteomic, and mechanistic studies identified the tyrosine kinase receptors EphB2 a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD031880 | Pride
Affinity pulldowns Kinobeads Lc-ms/ms 
ProteomicsChemoproteomic selectivity profiling of PIKK and PI3K kinase inhibitors
"Here, we report the development of a novel version of Kinobeads that extends kinome coverage to PIKK and PI3K kinases. This is achieved by inclusion of two affinity probes derived from the clinical PI3K/MTOR inhibitors Omipalisib and BGT226. The new affinity matrix was used to profile 13 clinical a...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD011719 | Pride
Chemoproteomics" "kinobeads Drug profiling 
UnknownDexamethasone Improves Cardiovascular Outcomes in Critically Ill COVID-19, a Real World Scenario Multicenter Analysis.
Not available
S-EPMC8847392 | biostudies-literature
UnknownHigher Incidence of Stroke in Severe COVID-19 Is Not Associated With a Higher Burden of Arrhythmias: Comparison With Other Types of Severe Pneumonia.
Not available
S-EPMC8652060 | biostudies-literature
UnknownMyocardial injury in severe COVID-19 is similar to pneumonias of other origin: results from a multicentre study.
Not available
S-EPMC7835505 | biostudies-literature
ProteomicsTarget Landscape of Clinical Kinase Inhibitors
Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related protein...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-12 | MSV000081932 | MassIVE
UnknownGenome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis.
Not available
S-EPMC8479862 | biostudies-literature
UnknownA genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies.
Not available
S-EPMC9976967 | biostudies-literature
UnknownAdd-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial.
Not available
S-EPMC12120674 | biostudies-literature
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