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ProteomicsDiscovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation
PKMYT1 has recently emerged as a compelling therapeutic target for precision cancer therapy due to its synthetic lethality with oncogenic alterations such as CCNE1 amplification and mutations in FBXW7 and PPP2R1A. Current small molecule PKMYT1 inhibitors face limitations, such as insufficient molecu...
ORGANISM(S): Homo sapiens (Human) 
2025-09-28 | PXD062889 | Pride
Protac Pkmyt1 Synthetic lethality Ai-generation 
ProteomicsHuman bladder cancer LC MS/MS
Urine is an ideal material to study and examine the bladder cancer (BCa) biomarkers, whereas exploration to the corresponding protein candidates is confronting technique challenges. Herein, we proposed a comprehensive strategy of searching the urine proteins related to BCa. The strategy consists of ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080696 | MassIVE
Proteomics,MultiomicsCHPP chr 1,8,20 proteome dataset using the HCC cell lines of Hep3B and MHCC97H, instrument is AB5600, part 3 of 3
The fresh cells as described above were harvested and lysed in buffer containing 8 M Urea, 50 mM NH4HCO3 and 5 mM IAA. The total cell lysates were centrifuged with 12,000 g for 10 min at 4 degrees Celsius to remove cell debris, and 1.5 mg proteins for each cell line were followed by sequential in-so...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-20 | MSV000080256 | MassIVE
Proteomics,MultiomicsCHPP chr 1,8,20 proteome dataset using the HCC cell lines of MHCC97H and HCCLM3, instrument is Q Exactive, part 1 of 3
The fresh cells as described above were harvested and lysed in buffer containing 8 M Urea, 50 mM NH4HCO3 and 5 mM IAA. The total cell lysates were centrifuged with 12,000 g for 10 min at 4 degrees Celsius to remove cell debris, and 1.5 mg proteins for each cell line were followed by sequential in-s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-20 | MSV000080255 | MassIVE
Proteomics,MultiomicsCHPP chr 1,8,20 proteome dataset using the HCC cell lines of Hep3B and MHCC97H, instrument is Q Exactive, part 2 of 3
The fresh cells as described above were harvested and lysed in buffer containing 8 M Urea, 50 mM NH4HCO3 and 5 mM IAA. The total cell lysates were centrifuged with 12,000 g for 10 min at 4 degrees Celsius to remove cell debris, and 1.5 mg proteins for each cell line were followed by sequential in-so...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-20 | MSV000080254 | MassIVE
ProteomicsGlobal protein data of proteomics of spleen infected by Babesia microti
Babesia is a kind of protozoa parasitic in the red blood cells of some vertebrates. Some species of Babesia can cause human and animal co-infection and do great harm. As the largest immune organ in mammals, spleen plays an important role in resisting Babesia infection. Although the spleen infected b...
ORGANISM(S): Babesia Microti 
2020-05-16 | PXD019236 |
ProteomicsPhosphorylated protein data of proteomics of spleen infected by Babesia microti
Babesia is a kind of protozoa parasitic in the red blood cells of some vertebrates. Some species of Babesia can cause human and animal co-infection and do great harm. As the largest immune organ in mammals, spleen plays an important role in resisting Babesia infection. Although the spleen infected b...
ORGANISM(S): Babesia Microti 
2020-05-21 | PXD019319 |
ProteomicsThe quantitative and phosphorylation proteomics analysis of mouse liver after tick-borne Babesia microti infection
Babesia microti is a tick-borne protozoan parasite that infects the red blood cells of mice, humans, and other mammals. Hosts infected with B. microti exhibit a series of clinical symptoms, including fever, anaemia, and haemoglobinuria, and multiple-organ injury. The infection can even result in dea...
ORGANISM(S): Mus Musculus 
2020-03-19 | PXD018102 |
ProteomicsOTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR
To explore the underlying mechanism by which OTUD6A induces PCa progression, we identified its binding proteins with an immunoprecipitation (IP)-mass spectrometry (MS) approach in two CRPC cell lines.
ORGANISM(S): Homo Sapiens 
2022-01-28 | PXD031307 |
ProteomicsProbing the Role of O-GlcNAcylation in Modulating Protein-DNA Interactions: Insights from a Proteomic Transcription Factor Response Element-Based Pulldown Screening Approach
O-linked β-N-acetylglucosamine (O-GlcNAc), a critical post-translational modification (PTM) predominantly found in the nucleus, plays a substantial role in regulating gene expression by modulating transcription factors (TFs) activity. Herein, by utilizing a pulldown screening approach termed as tand...
ORGANISM(S): Homo Sapiens 
2024-10-24 | PXD057128 |
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