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TranscriptomicsTranscriptome signature in early biopsies of stably functioning kidney allografts identify patients at risk for chronic injury
Chronic injury in kidney transplants remains a major cause of graft loss. The aim of this study was to identify a predictive gene set capable of classifying renal grafts at risk for progressive injury due to fibrosis.The Genomics of Chronic Allograft Rejection (GoCAR) study is a prospective, multice...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-57387 | biostudies-arrayexpress
TranscriptomicsThe Role of Macrophages in the Development of Human Renal Allograft Fibrosis in the First Year after Transplantation
The aim of this study was to investigate the role of infiltrating macrophages in renal allograft fibrosis. Forty-six protocol renal allograft biopsies obtained one-year after transplantation were stained with Sirius Red to quantify fibrosis and double stained with CD68 and CD206 to identify the prop...
ORGANISM(S): Homo sapiens 
2015-01-28 | E-GEOD-65326 | biostudies-arrayexpress
TranscriptomicsMolecular heterogeneity in acute renal allograft rejection
The data set contains 67 array (lymphochip cDNA array), published in N Engl J Med 2003 Jul 10;349(2):125-38. PMID: 12853585. TITLE: Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. BACKGROUND: The causes and clinical course of acute rejection vary, a...
ORGANISM(S): Homo sapiens 
2003-07-01 | E-GEOD-343 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human renal allograft biopsies reveal conserved rejection signatures and molecular pathways I
Specific early diagnosis of renal allograft rejection is gaining importance in the current trend to minimize and individualize immunosuppression. Gene expression analyses could contribute significantly by defining “molecular Banff” signatures. Several previous studies have applied transcriptomic...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-9489 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analyses of renal allograft biopsies reveal conserved rejection signatures and molecular pathways
Transcriptomic analyses of renal allograft biopsies reveal conserved rejection signatures and molecular pathways. GEO SuperSeries. This dataset is part of the TransQST collection.
ORGANISM(S): Homo sapiens 
2009-02-24 | E-GEOD-9493 | biostudies-arrayexpress
TranscriptomicsGene Expression Test for Operational Renal Allograft Tolerance
Genomic Analysis of more than 400 patients from multi-center transplant programs and clinical trials provides a non-invasive QPCR based gene expression test for operational renal allograft tolerance 3 group comparison of blood from TOL, CAN and Non-transplant healthy controls (HD) allografts. Biolog...
ORGANISM(S): Homo sapiens 
2015-01-08 | E-GEOD-45218 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood lymphocytes (PBL) from four pediatric renal allograft recipients with acute rejection and concurrent anemia
Compromised renal function after renal allograft transplantation often results in anemia in the recipient. Molecular mechanisms leading to anemia during acute rejection are not fully understood; inadequate erythropoietin production and iron deficiency have been reported to be the main contributors. ...
ORGANISM(S): Homo sapiens 
2005-11-01 | E-SMDB-2730 | biostudies-arrayexpress
TranscriptomicsDe novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function
Background: Despite significant improvements in short-term kidney transplant survival, comparable increases in 5 and 10-year outcomes have not been achieved. Chronic allograft nephropathy (CAN) is a major cause of late graft loss. Toxic nephropathy and inadequate long-term immunosuppression are poss...
ORGANISM(S): Homo sapiens 
2004-09-23 | E-GEOD-1743 | biostudies-arrayexpress
ProteomicsProteomic analysis of renal biomarkers of kidney allograft fibrosis – a study in renal transplant patients
Renal transplantation is the preferred treatment of end stage renal disease, but allograft survival is limited by development of interstitial fibrosis and tubular atrophy in response to various stimuli. Much effort has been put into identifying new protein markers of fibrosis to support the diagnosi...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD017867 | Pride
Nano-lc-msms Transplant Kidney fibrosis 
TranscriptomicsIntragraft molecular pathways associated with tolerance induction in renal transplantation
Complications associated with immunosuppression, specifically nephrotoxicity and infection risk, significantly affect graft and patient survival after kidney transplantation. We previously showed that tolerance could be induced and full donor chimerism, as well as immunosuppression withdrawal, was o...
ORGANISM(S): Homo sapiens 
2018-05-07 | E-GEOD-106675 | biostudies-arrayexpress
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