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TranscriptomicsTranscription profiling of chromophobe renal cell carcinoma and oncocytoma samples
[original title] Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma. Background : Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma are two distinct but closely related entities with strong morphologic and geneti...
ORGANISM(S): Homo sapiens 
2010-07-08 | E-GEOD-19982 | biostudies-arrayexpress
TranscriptomicsChromophobe and Oncocytoma Renal Cell Carcinomas: gene expression and SNP analysis
Chromosomal abnormalities, such as structural and numerical abnormalities, are a common occurrence in cancer. The close association of homologous chromosomes during interphase, a phenomenon termed somatic chromosome pairing, has been observed in cancerous cells, but the functional consequences of so...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-8271 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human chromophobe renal cell carcinoma and oncocytoma
This study aims to compare gene expression profiles of chromophobe renal cell carcinoma (RCC) and benign oncocytoma, aiming at identifying differentially expressed genes. Experiment Overall Design: Nine cases each of chromophobe RCC and oncocytoma were analyzed by oligonucleotide microarray. Candid...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12090 | biostudies-arrayexpress
ProteomicsChromophobe renal cell carcinoma versus renal oncocytoma: a proteomic approach
The proteome of clinical tissue samples diagnosed with chromophobe renal cell carcinomas (chRCC) and renal oncocytomas (RO) were evaluated to establish a potential discriminative biomarker panel of proteins for these two tumors subtypes.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD022018 | Pride
Mass spectrometry Renal cancer Chromophobe renal cell carcinoma Proteins Biomarkers renal oncocytoma 
TranscriptomicsGene expression profiling of BHDS-associated renal tumors
Renal tumors that arise in individuals with BHD Syndrome represent a molecularly distinct form of renal cancer. In addition, BHD syndrome is due to a mutation the folliculin gene (FLCN). While the folliculin gene is an important tumor suppressor gene, the molecular function of this gene is not well...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-21816 | biostudies-arrayexpress
ProteomicsRenal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione
Renal oncocytomas are rare benign tumors of the kidney and are characterized by a deficient complex I (CI) enzyme activity of the oxidative phosphorylation (OXPHOS) system caused by mitochondrial DNA (mtDNA) mutations. Yet, little is known about the underlying molecular mechanisms and alterations of...
ORGANISM(S): Homo sapiens (Human) 
2017-11-21 | PXD007633 | Pride
Renal oncocytoma - complex i deficiency - glutathione metabolism - mtdna mutation 
ProteomicsRenal cell carcinoma: a proteomic approach
The proteome of clinical tissue samples diagnosed with clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC) were evaluated analyzed along with the dataset identifier PXD022018 to establish a potential discriminative biomarker panel of proteins for these tumors subtypes.
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD023296 | Pride
Clear cell renal cell carcinoma Renal oncocytoma Mass spectrometry Label-free quantification. Renal tumors Chromophobe renal cell carcinoma Papillary renal cell carcinoma Proteins Biomarkers 
TranscriptomicsGene expression and SNP profiling discriminates chromophobe renal cell carcinoma and oncocytoma
Gene expression profiles, high-throughput SNP genotyping, and pathway analysis effectively distinguish chRCC from oncocytoma.  We have generated a novel transcript predictor that is able to discriminate between the two entities accurately, and which has been validated both in an internal and an inde...
ORGANISM(S): Homo sapiens 
2011-02-02 | E-GEOD-20376 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human kidney samples to discover gene signatures of progression and metastasis in renal cell cancer
In order to address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC), transcriptional profiling with oligonucleotide microarrays (22,283 genes) was done on 49 RCC tumors, 20 non-RCC renal tumors, and 23 normal kidney samples. Samples were clustered based on gene exp...
ORGANISM(S): Homo sapiens 
2009-04-28 | E-GEOD-15641 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling in renal cell carcinoma subtypes
Renal cell carcinoma is the most common neoplasm of the adult kidney. A few subtypes of RCC include papillary RCC (pRCC), chromophobe RCC (chRCC) and the benign oncocytoma tumor. In some cases, distinguishing between the RCC subyptes is difficult. We performed a mircroRNA (miRNA) microarray to deter...
ORGANISM(S): Homo sapiens 
2012-08-13 | E-GEOD-39790 | biostudies-arrayexpress
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