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ProteomicsImpact of glycan positioning on HIV-1 Env glycan shield density, function, and antibody recognition
N-glycans, which represent >50% mass of the HIV-1 envelope (Env) trimer, play important roles for virus-cell entry and immune evasion. How each glycan unit interacts to shape the Env protein-sugar complex and affects Env function is not well understood. Here, high-resolution glycomics analysis of ...
ORGANISM(S): HIV-1 M:G_PT919 
2021-09-09 | PXD017941 | Pride
Glycosylation Env Hiv N262 Gp120 
ProteomicsSerum proteomic analysis of circulating IgA1-containing immune complexes in patients with IgA nephropathy
IgA nephropathy (IgAN) is an autoimmune disease that involves galactose-deficient IgA1 (Gal-deficient IgA1) recognized by autoantibodies to form circulating immune complexes (IgA1-IC). Some of these complexes deposit in the glomeruli and induce kidney injury. Gal-deficient IgA1 alone is not sufficie...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD055562 | Pride
Proteomics Lc-ms Complement Orbitrap Raw Immune complexes Serum Iga nephropathy Glomerular disease 
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