Sort   by:  
 Page size 
TranscriptomicsTranscriptional response of Pseudomonas aeruginosa PAO1 to human host defense peptide LL-37
In this experiment the transcriptional response of the opportunistic human pathogen Pseudomonas aeruginosa towards physiological concentrations of the major human host defense peptide LL-37 was investigated using microarrays. To this aim, three independent cultures of P. aeruginosa PAO1 were grown u...
ORGANISM(S): Pseudomonas aeruginosa 
2013-12-20 | E-MEXP-3970 | biostudies-arrayexpress
UnknownCharacterization of Affitin proteolytic digestion in biorelevant media and improvement of their stabilities via protein engineering.
Not available
S-EPMC7661517 | biostudies-literature
Proteomics,MultiomicsmiR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signaling in human colorectal adenocarcinoma cells
Oxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major unsolved problem. Consequently, predictive markers and a better understanding of resistance mechanisms are urgently needed. To investigate if the recently identified predictive miR-625-3p is functionally involved in oxPt resistance...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080762 | MassIVE
ProteomicsStress-induced changes in the lipid microenvironment of β-(1,3)-D-glucan synthase cause clinically important echinocandin resistance in Aspergillus fumigatus
Aspergillus species are a leading cause of invasive fungal infections. As resistance to first-line therapy involving triazole antifungal agents is rising, second-line therapy with echinocandins is expanding. Resistance to echinocandins is well-established to result from amino acid substitutions in t...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2019-09-03 | PXD012438 | Pride
Aspergillus fumigatus Echinocandin resistance Caspofungin Posttranslational modifications Lc-ms/ms 
UnknownGlycosylation Contributes to Thermostability and Proteolytic Resistance of rFIP-nha (Nectria haematococca).
Not available
S-EPMC10490071 | biostudies-literature
ProteomicsOptimized Digestion Conditions for Membrane Protein Foot-printing and Mass Spectrometry Analysis
Integral membrane proteins (IMPs), which constitute 50–60% of drug targets, play essen-tial roles in numerous biological processes but remain underrepresented in conventional bottom-up and in structural proteomics owing to their hydrophobicity and resistance to proteolysis. Although advances in IMPs...
ORGANISM(S): Homo sapiens (Human) 
2026-07-02 | PXD072461 | Pride
Membrane protein  vitamin k epoxide reductase (vkor)  mass spectrometry  protein footprinting  filter-aided sample preparation (fasp) Membrane protein digestion 
ProteomicsHeat and pressure resistance relates to protein folding and aggregation
The locus of heat resistance (LHR) confers extreme heat resistance in E. coli. This study explored the role of the LHR in pressure resistance of E. coli, as well as its relationship with protein folding and aggregation in vivo. The role of LHR was investigated in E. coli MG1655 expressing a ibpA-yfp...
ORGANISM(S): Escherichia coli 
2020-01-27 | PXD011023 | Pride
Food preservation Escherichia coli Pressure resistance Inclusion bodies 
ProteomicsResistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL), making the Notch signaling pathway a promising therapeutic target for personalized medicine. Yet, a major limitation for long-term success of targeted therapy is relap...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038908 | Pride
Combination therapies Pik3r1 Notch1 Resistance mechanisms T-all 
UnknownAdhesive Virulence Factors of Staphylococcus aureus Resist Digestion by Coagulation Proteases Thrombin and Plasmin.
Not available
S-EPMC9782320 | biostudies-literature
UnknownMotif mapping during chickpea germination reveals a complex sequential activation of different proteolytic activities.
Not available
S-EPMC11527212 | biostudies-literature
Sort   by:  
 Page size