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Transcriptomicsp53 amplifies Toll-like receptor 5 response in MCF-7 cells
Using gene expression profiling we characterize the global effect of p53 on the TLR5-mediated transcription in MCF7 cells. We found that combined activation of p53 and TLR5 pathways synergistically increases expression of over 200 genes, mostly associated with immunity and inflammation. The synergy ...
ORGANISM(S): Homo sapiens 
2015-08-26 | E-GEOD-72359 | biostudies-arrayexpress
TranscriptomicsBand-array detection of chromosomal rearrangements in diploid yeast cells exposed to ionizing radiation
At the organismal level, genome rearrangements are usually deleterious and are often associated with disease. Yet, on an evolutionary scale, they can be beneficial as they provide for rapid genetic diversification. DNA lesions, particularly double-strand breaks (DSBs), are sources of genome instab...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-6991 | biostudies-arrayexpress
TranscriptomicsCGH detection of chromosomal rearrangements in diploid yeast cells exposed to ionizing radiation
At the organismal level, genome rearrangements are usually deleterious and are often associated with disease. Yet, on an evolutionary scale, they can be beneficial as they provide for rapid genetic diversification. DNA lesions, particularly double-strand breaks (DSBs), are sources of genome instab...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-6984 | biostudies-arrayexpress
TranscriptomicsDiverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells (Affymetrix)
The effects of diverse stresses on promoter selectivity and transcription regulation by the tumor suppressor p53 are poorly understood. We have taken a comprehensive approach to characterizing the human p53 network that includes p53 levels, binding, expression and chromatin changes under diverse str...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-46493 | biostudies-arrayexpress
UnknownA multiplex method for rapidly identifying viral protease inhibitors
Not available
S-SCDT-10_1038-S44320-024-00082-1 | biostudies-other
UnknownExposure to fine particulate matter and temporal dynamics of episodic memory and depressive symptoms in older women.
Not available
S-EPMC7499893 | biostudies-literature
GenomicsWhole genome sequencing with linked reads of pediatric glioblastoma samples
Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand mechanisms of tumor evolution in this cancer, we performed whole genome sequencing with linked reads on longitudinally resected pGBM samples. Our analyses showed that all diagnostic and recurrent samples were...
EGAS00001003432 | EGA
UnknownIntratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma.
Not available
S-EPMC7282886 | biostudies-literature
Genomics3a29872b-a736-415c-b42b-d2ee95d79c54 - samples
WGS with linked reads of pediatric glioblastoma. For each patient, blood and tumor tissue were sequenced. For two patients, we also provide sequencing data for the blood of their parents.
EGAD00001005212 | EGA
GenomicsCharbonneau Cancer Institute DAC
Data Access Committee EGAC00001001280
EGAC00001001280 | EGA
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