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TranscriptomicsGene expression data for worker honey bees experimentally exposed to a dual infection with Deformed wing virus and Nosema ceranae.
Bees from 3 unrelated colonies were injected with 1ul PBS extract containing 10^9 genome equivalent of Deformed wIng virus (DWV) and/or fed 10µl sucrose solution containing 10^5 fresh Nosema ceranae spores. Control bees were injected and fed with an equivalent DWV- and Nosema-free extract respectiv...
ORGANISM(S): Apis mellifera 
2017-03-08 | E-MTAB-5508 | biostudies-arrayexpress
ModelsModel of the pH-induced metabolic shift in phosphate-limited continuous cultures of C. acetobutylicum assuming a phenotypic switch
Model of the pH-induced metabolic shift in phosphate-limited continuous cultures of C. acetobutylicum assuming a phenotypic switch
2013-01-06 | 100 | FAIRDOMHub
TranscriptomicsTranscription profiling of human MCF7 cells following short-term E deprivation, ER-alpha siRNA knockdown and oxidant treatments
To investigate the oxidant sensitivity of E/ER regulated gene expression, E/ER regulated genes are identified using E deprivation or; ER-alpha siRNA knockdown; and oxidative stress responsive is determined by 8hr exposure to diamide, hydrogen peroxide and menadione Experiment Overall Design: MCF7 ce...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-10061 | biostudies-arrayexpress
MetabolomicsOGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis

Acute Myeloid Leukemia (AML) commonly relapses after initial chemotherapy response. We assessed metabolic adaptations in chemoresistant cells in vivo before overt relapse, identifying altered branched-chain amino acid (BCAA) levels in patient-derived xenografts (PDX) and immunophenotypically iden...

2025-07-19 | MTBLS10255 | MetaboLights
TranscriptomicsscRNAseq of olfactory mucosa and olfactory bulb of WT and Tspo knockout rats
We utilized single-cell RNA sequencing to examine gene expression changes in olfactory mucosa and olfactory bulb cells following knockout of translocator protein (18 kDa; Tspo) in Sprague Dawley rats. Tspo has been found to be highly expressed in the olfactory system in normal physiological conditio...
ORGANISM(S): Rattus norvegicus 
2026-10-09 | E-MTAB-15825 | biostudies-arrayexpress
TranscriptomicsComprehensive array CGH of normal karyotype Myelodysplastic syndrome reveals hidden recurrent and individual genomic copy number aberrations with prognostic relevance
About 40% of patients with myelodysplastic syndromes (MDS) present with a normal karyotype and they are facing different courses of disease. To advance the biological understanding and find molecular prognostic markers we performed a high resolution oligonucleotide array study of 107 MDS patients (F...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-24602 | biostudies-arrayexpress
TranscriptomicsBone morphogenetic protein-7 is a MYC target with pro-survival functions in childhood medulloblastoma
Medulloblastoma (MB) is the most common malignant brain tumor in children, among whom overexpression or amplification of MYC oncogenes has been associated with poor clinical outcome. Although the MYC functions during normal development and oncogenesis in various systems have been extensively investi...
ORGANISM(S): Homo sapiens 
2011-05-16 | E-GEOD-22139 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human HepG2 cells treated with false positive genotoxins, true genotoxins and non-genotoxins
In this study we aimed to identify the molecular pathways modified by the false positive genotoxins Quercetin, 8-Hydroxyquinoline and 17beta-Estradiol that may explain their in vitro genotoxic and their in vivo non-genotoxic effects, by combining in vitro transcriptomics with phenotypic data. The ef...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-MEXP-2574 | biostudies-arrayexpress
TranscriptomicsCytosolic Phospholipase A2M-NM-1 and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation
The role of Group IVA cytosolic phospholipase A2 (cPLA2M-NM-1) activation in regulating macrophage transcriptional responses to Candida albicans infection was investigated. cPLA2M-NM-1 releases arachidonic acid for the production of eicosanoids. In mouse resident peritoneal macrophages, prostacycli...
ORGANISM(S): Mus musculus 
2013-05-02 | E-GEOD-46533 | biostudies-arrayexpress
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
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