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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
GenomicsRESTRICTION checkpoint controls bradyzoite development in Toxoplasma gondii
RESTRICTION checkpoint controls bradyzoite development in Toxoplasma gondii
PRJNA827772 | ENA
GenomicsMitochondrial homeostasis of endocrine organ navigates nutrient restriction checkpoint
Mitochondrial homeostasis of endocrine organ navigates nutrient restriction checkpoint
PRJNA1110747 | ENA
TranscriptomicsAn RNAi screen probing signalling control of human embryonic stem cells establishes the cell cycle-regulated restriction of the exit from pluripotency (DNA damage checkpoint)
Analysis of effect of S-phase arrest and replication checkpoint activation on differentiating hESCs at the gene expression level. The hypothesis tested in the present study was that replication checkpoint activation prevents the exit from pluripotency in hESCs. Results provide important information ...
ORGANISM(S): Homo sapiens 
2015-07-28 | E-GEOD-62062 | biostudies-arrayexpress
UnknownIncreased response to immune checkpoint inhibitors with dietary methionine restriction.
Not available
S-EPMC10104076 | biostudies-literature
UnknownRestriction Checkpoint Controls Bradyzoite Development in Toxoplasma gondii.
Not available
S-EPMC9241953 | biostudies-literature
TranscriptomicsRESTRICTION checkpoint controls bradyzoite development in Toxoplasma gondii
The Toxoplasma gondii G1 RESTRICTION checkpoint operates the switch between parasite growth and differentiation. The Cdk-related G1 kinase TgCrk2 forms alternative complexes with atypical cyclins (TgCycP1, TgCycP2 and TgCyc5) in the rapidly dividing developmentally incompetent RH and slower dividing...
ORGANISM(S): Toxoplasma gondii 
2022-04-23 | GSE200962 | GEO
ProteomicsTgCrk2 interactome in Toxoplasma gondii RH and ME49 parasites
Although apicomplexans lack conventional R-point regulators, presence of the quiescent G1 forms of 43 parasites, including mature T. gondii bradyzoites suggests that a functional RESTRICTION checkpoint 44 exists in apicomplexan parasites. We showed that Cdk-related G1 kinase TgCrk2 forms alternative...
ORGANISM(S): Toxoplasma gondii ME49 
2022-08-12 | PXD033109 | Pride
Restriction checkpoint Toxoplasma gondii Crk Tachyzoite Cyclin Differentiation Cell cycle Bradyzoite 
TranscriptomicsMitochondrial homeostasis of endocrine organ navigates nutrient restriction checkpoint
Steroid hormones are powerful endocrine regulators, but little is known about the integration of their production with environmental conditions. Here, we use Drosophila prothoracic gland (PG) to examine how insect steroid hormone production navigates a developmental checkpoint critical for juvenile-...
ORGANISM(S): Drosophila melanogaster 
2024-12-02 | GSE267248 | GEO
GenomicsDietary methionine restriction primes T cell metabolism for activation and tumor inhibition and enhances the efficacy of immune checkpoint blockade
Dietary methionine restriction primes T cell metabolism for activation and tumor inhibition and enhances the efficacy of immune checkpoint blockade
PRJNA1365318 | ENA
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