Sort   by:  
 Page size 
ProteomicsRestrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription
Transcription termination pathways mitigate the detrimental consequences of unscheduled promiscuous initiation occurring at hundreds of thousands of genomic cis-regulatory elements. The Restrictor complex, composed of the Pol II-interacting protein WDR82 and the RNA-binding protein ZC3H4, suppresses...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD043638 | Pride
Ranscription termination Zc3h4 
ProteomicsPP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA pol II transcription termination
The restrictor, ZC3H4/WDR82, terminates antisense transcription from bidirectional promoters, but its mechanism is poorly understood. We report that ZC3H4/WDR82 immunoprecipitate with PP1 phosphatase and its nuclear targeting subunit, PNUTS, which binds to WDR82. AlphaFold predicts a complex of PP1/...
ORGANISM(S): Homo sapiens (Human) 
2025-04-06 | PXD061598 | Pride
Pp1 phosphatase Ctd dephosphorylation Zc3h4 Pol ii ctd ser5 phosphorylation Restrictor Wdr82 Transcription termination Transcription elongation 
UnknownRestrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription.
Not available
S-EPMC10760643 | biostudies-literature
UnknownRestrictor slows RNAPII elongation to promote termination at noncoding RNA loci.
Not available
S-EPMC12211998 | biostudies-literature
GenomicsSequential verification of transcription by Integrator and Restrictor [U170K_POINT-seq]
Sequential verification of transcription by Integrator and Restrictor [U170K_POINT-seq]
PRJNA1265244 | ENA
GenomicsSequential verification of transcription by Integrator and Restrictor [ZC3H4_mNET-seq]
Sequential verification of transcription by Integrator and Restrictor [ZC3H4_mNET-seq]
PRJNA1265248 | ENA
GenomicsSequential verification of transcription by Integrator and Restrictor [ZC3H4_EXOSC3_nucRNA-seq]
Sequential verification of transcription by Integrator and Restrictor [ZC3H4_EXOSC3_nucRNA-seq]
PRJNA1265251 | ENA
GenomicsSequential verification of transcription by Integrator and Restrictor [ZC3H4_INTS4_chrRNA-seq]
Sequential verification of transcription by Integrator and Restrictor [ZC3H4_INTS4_chrRNA-seq]
PRJNA1265238 | ENA
GenomicsSequential verification of transcription by Integrator and Restrictor [INTS4_U1AMO_chrRNA-seq]
Sequential verification of transcription by Integrator and Restrictor [INTS4_U1AMO_chrRNA-seq]
PRJNA1265243 | ENA
UnknownPP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA Pol II transcription termination.
Not available
S-EPMC12187157 | biostudies-literature
Sort   by:  
 Page size