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ProteomicsThe proteome of normal human retina
The retina is a delicate tissue that detects light, converts photochemical energy into neural signals, and transmits the signals to the visual cortex of the brain. A detailed protein inventory of the proteome of the normal human eye may provide a foundation for new investigations into both the physi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-26 | MSV000079537 | MassIVE
ProteomicsProteomics analysis of guinea pig retina at the early stage of myopia
This is a combined SWATH database of early myopic guinea pig retina. The retinal tissues were divided into lens induced myopia 4 days group (4-day LIM) and control group; 5 individual animals (10 retinas) were included. The potential biomarkers and underlying biochemical pathways during early myopia...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2021-05-13 | PXD025003 | Pride
Proteomics guinea pig retina myopia 
ProteomicsProteomic profiling of embryonic retina to facilitate ocular disease gene discovery
To expedite gene discovery in eye development and its associated defects, we previously developed a bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene discovery). However, iSyTE is presently limited to lens tissue and is predominantly based on transcriptomics datasets. Therefor...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD039490 | Pride
Gene discovery Proteome Embryogenesis Retina Mass spectrometry Isyte Development 
ProteomicsThe proteome of normal human retina
The retina is a delicate tissue that detects light, converts photochemical energy into neural signals, and transmits the signals to the visual cortex of the brain. A detailed protein inventory of the proteome of the normal human eye may provide a foundation for new investigations into both the physi...
ORGANISM(S): Homo sapiens (Human) 
2014-11-27 | PXD001242 | Pride
Age-related macular degeneration / eye / human / retina / phototransduction / proteome 
Proteomics17β-Estradiol Delivered in Eye Drops: A Proteomics Study Focusing on the Rat Retina
Five ovariectomized (OVX) Brown Norway rats (Charles Rivers Laboratories, Wilmington, DE, USA) weighing 200-250 g received 10 µL of 17β-estradiol (E2) eye drops once daily in both eyes for three weeks [20]. The eye drops contained 0.1% (w/v) E2 in saline vehicle containing 20% (w/v) 2-hydroxypropyl-...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-27 | PXD010851 | Pride
Retina Datadependent acquisition Rat Label-free Estradiol 
ProteomicsFirst identification of ITM2B interactome in the human retina
ITM2B is a type II ubiquitous transmembrane protein which role remains unclear. ITM2B mutations have been associated with different disorders: mutations leading to longer mutant proteins have been reported in two distinct Alzheimer-like autosomal dominant disorders with early-onset progressive demen...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020088 | Pride
Ap-ms Human Itm2b Retina Interactome 
ProteomicsRat retina and optic nerve LC-MS/MS
Various retinal disorder such as glaucomatous, retinal ischemia reperfusion, and traumatic optic neuropathy, are involved in the pathogenesis of neurodegeneration via glutamate exicitotoxicity. However, the proteomic characteristics and modulation of the neural-microenvironment with NMDA-induced neu...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-12-30 | PXD022729 | Pride
Rat Optic nerve Retina Lc-ms/ms 
ProteomicsRat retina and optic nerve LC-MS/MS
Various retinal disorder such as glaucomatous, retinal ischemia reperfusion, and traumatic optic neuropathy, are involved in the pathogenesis of neurodegeneration via glutamate exicitotoxicity. However, the proteomic characteristics and modulation of the neural-microenvironment with NMDA-induced neu...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-12-30 | PXD022466 | Pride
Rat Optic nerve Retina Lc-ms/ms 
OtherThe proteome of human retina.
Data from ProteomeXchange, PXD ID: PXD001242. File: KYCzx3yI-6939_8.mgf. Published as part of Proteomics. 2014 Nov 19 . From the Abstract: {{i}} The retina is a delicate tissue that detects light, converts photochemical energy into neural signals, and transmits the signals to the visual cortex of t...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320005063 | GPMDB
Resource Reanalysis 
ProteomicsHuman Retina Proteomics - Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
Differences in regional protein expression within the human retina may explain molecular predisposition of specific regions to ophthalmic diseases like age-related macular degeneration, cystoid macular edema, retinitis pigmentosa, and diabetic retinopathy. To quantify protein levels in the human ret...
ORGANISM(S): Homo sapiens (Human) 
2018-02-26 | PXD008462 | Pride
Metabolism Retinal degeneration Proteomics Retina Oxidative stress Precision medicine Biomarker 
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