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MetabolomicsRetromer mediates Ypt7-dependent lipid droplet internalization

Lipid droplets (LDs) are dynamic organelles central to cellular energy homeostasis and stress adaptation. Maintaining LD balance is critical for cell function, yet the mechanisms governing selective LD degradation remain unclear. Here, we reveal a pathway promoting efficient vacuolar sequestering...

2026-07-15 | MTBLS15038 | MetaboLights
GenomicsThe retromer complex promotes apoptotic cell degradation during efferocytosis
The retromer complex promotes apoptotic cell degradation during efferocytosis
PRJNA1367063 | ENA
ProteomicsSNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion
Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential role of SNX3-ret...
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD010632 | Pride
Retromer flippase snx3 
GenomicsEnhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease
Enhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease
PRJNA1113999 | ENA
ProteomicsRetriever is a multiprotein complex for retromer-independent endosomal cargo recycling
Following endocytosis into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multiprotein complex which orchestrates cargo retrieval and recycl...
ORGANISM(S): Homo sapiens (Human) 
2018-01-15 | PXD007230 | Pride
Snx17 Retriever Retromer 
ProteomicsCROP: A Retromer- PROPPIN complex mediating membrane fission in the endo-lysosomal system
Endo-lysosomal compartments exchange proteins by fusing, fissioning, and through endosomal transport carriers. Thereby, they sort many plasma membrane receptors and transporters and control cellular signaling and metabolism. How the membrane fission events are catalyzed is poorly understood. Here, w...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-05-05 | PXD031244 | Pride
Endo-lysosomal system Yeast 
GenomicsLysosomal Downregulation of the Mu Opioid Receptor is Opposed by the Retromer Complex
Lysosomal Downregulation of the Mu Opioid Receptor is Opposed by the Retromer Complex
PRJNA1193518 | ENA
UnknownA luminescent reporter assay to quantify SORL1 ectodomain shedding and retromer-dependent endosome recycling activity.
Not available
S-EPMC12860930 | biostudies-literature
TranscriptomicsEnhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease
Synaptic dysfunction is an early hallmark of Alzheimer’s disease, characterized by the disruption of synaptic transmission and plasticity. Central to these processes is endosomal trafficking, mediated by the retromer complex, which orchestrates the movement of vesicle contents for recycling to the p...
ORGANISM(S): Mus musculus 
2025-09-17 | GSE267989 | GEO
TranscriptomicsThe retromer complex promotes apoptotic cell degradation during efferocytosis
Efficient clearance of dead cells, termed efferocytosis, is essential for maintaining tissue homeostasis. Although the cellular and molecular mechanisms regulating apoptotic cell (AC) internalization are well established, our understanding of AC digestion upon engulfment remains elusive. Here, we sh...
ORGANISM(S): Mus musculus 
2025-11-25 | GSE310776 | GEO
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