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TranscriptomicsA retrotransposon-driven Dicer variant enhances endogenous RNAi in mouse oocytes
Mammals have one Dicer gene required for biogenesis of small RNAs in microRNA (miRNA) and RNA interference (RNAi) pathways. Yet, endogenous RNAi is highly active in oocytes but not in somatic cells. Here, we provide a mechanistical explanation for high RNAi activity in mouse oocytes. The main Dicer ...
ORGANISM(S): Mus musculus 
2013-11-07 | E-GEOD-41207 | biostudies-arrayexpress
GenomicsLTR-retrotransposon control by tRNA-derived small RNA
LTR-retrotransposon control by tRNA-derived small RNA
PRJNA324286 | ENA
GenomicsRetrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro B cells
The establishment of distinct transcription programs during development is controlled by transcription factor networks acting in specific chromatin environments. The H3K9me3-specific histone methyltransferase Setdb1 impacts on transcriptional regulation by repressing both developmental genes and ret...
ORGANISM(S): Mus musculus 
2016-07-20 | E-GEOD-77636 | biostudies-arrayexpress
TranscriptomicsTranscriptomics of Arabidopsis thaliana wild-type and nrpd1-3 under control or heat stress
The intent of the experiment was to infer from transcriptome data the differential activation of LTR retrotransposon family members from Onsen/COPIA78, an Arabidopsis thaliana's heat-activated retrotransposon. For this, we performed Illumina 150 bp pair-end RNA-seq, in both wild-type Col-0 and RdDM ...
ORGANISM(S): Arabidopsis thaliana 
2019-03-17 | E-MTAB-5643 | biostudies-arrayexpress
ProteomicsUBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
Amyotrophic Lateral Sclerosis (ALS) is a rare neurodegenerative disease characterized by motor neuron dysfunction and loss, leading to progressive paralysis and death. A portion of ALS cases is caused by mutation of the proteasome shuttle factor Ubiquilin 2 (UBQLN2), but the molecular pathway leadin...
ORGANISM(S): Homo sapiens (Human) 
2023-03-24 | PXD031964 | Pride
Q-exactive hf-x Tmt Als Human spinal cord 
GenomicsDNA sequencing of Arabidopsis thaliana wild-type and nrpd1-3 under control or heat stress
The intent of the experiment was to infer from DNA sequencing the occurrence of extra-chromosomal DNA from Arabidopsis thaliana's heat-activated LTR retrotransposon Onsen/COPIA78. For this, we performed Illumina 150 bp pair-end PCR-free DNA genome re-sequencing, in both wild-type Col-0 and RdDM muta...
ORGANISM(S): Arabidopsis thaliana 
2018-03-18 | E-MTAB-5641 | biostudies-arrayexpress
TranscriptomicsArgonaute proteins affect siRNA levels and accumulation of a novel extrachromosomal DNA from the Dictyostelium retrotransposon DIRS-1
We report on the function of the D. dictyostelium argonaute proteins AgnA and AgnB in the silencing mechanism of the retrotransposon DIRS-1. By deep sequencing analysis we found that AgnA is involved in the accumulation of DIRS-1 siRNAs since in respective knockout strains siRNAs are strongly reduce...
ORGANISM(S): Dictyostelium discoideum 
2014-12-04 | E-GEOD-56111 | biostudies-arrayexpress
ProteomicsChAHP and ChAHP2 control diverse retrotransposons by complementary activities.
Retrotransposon control in mammals is an intricate process that is effectuated by a broad network of chromatin regulatory pathways. We previously discovered ChAHP, a protein complex with repressive activity against SINE retrotransposons, composed of the transcription factor ADNP, chromatin remodeler...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-05 | PXD048310 | Pride
Adnp2 Mouse esc Hp1 Chd4 Retrotransposon control Adnp 
ProteomicsChAHP and ChAHP2 control diverse retrotransposons by complementary activities.
Retrotransposon control in mammals is an intricate process that is effectuated by a broad network of chromatin regulatory pathways. We previously discovered ChAHP, a protein complex with repressive activity against SINE retrotransposons, composed of the transcription factor ADNP, chromatin remodeler...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-05 | PXD048314 | Pride
Adnp2 Mouse esc Hp1 Chd4 Retrotransposon control Adnp 
UnknownLTR-Retrotransposon Control by tRNA-Derived Small RNAs.
Not available
S-EPMC5551035 | biostudies-literature
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