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TranscriptomicsHP1, H3-K27me3, and H3-K9me3 Cut & Tag of Het (Cbx1+/+, Cbx3+/+, Cbx5+/-) and TKO (Cbx1-/-, Cbx3-/-, Cbx5-/-) bipotential mouse embryonic liver (BMEL) cells
Cut & Tag was used to localize the 3 mouse HP1 proteins (Cbx1,Cbx3,Cbx5) to the genome of BMEL (bipotential mouse embryonic liver) cells. Het BMEL cells are Cbx1+/+, Cbx3+/+, Cbx5+/- HP1-TKO (triple knock-out cells) are Cbx1-/-, Cbx3-/-, Cbx5-/-. The HP1_TKO cells were used to verify the specificity...
ORGANISM(S): Mus musculus 
2025-06-14 | E-MTAB-15189 | biostudies-arrayexpress
GenomicsProteo-Genomic Characterization and Mapping of Nucleosomes Decoded by Brd and HP1 Proteins (Chip-Seq data)
Background: Histone post-translational modifications (PTMs) constitute a branch of epigenetic mechanisms that can control the expression of eukaryotic genes in a heritable manner. Recent studies have identified several PTM-binding proteins containing diverse specialized domains whose recognition of ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-39579 | biostudies-arrayexpress
TranscriptomicsChromatin IP of POF, HP1 and H3K9ac in S2 cells and salivary glands.
Two chromosome-targeting and gene regulatory systems are present in Drosophila melanogaster. The male X-chromosome is targeted by the male-specific lethal complex believed to mediate the two-fold up-regulation of the X-linked genes. The highly heterochromatic 4th chromosome is specifically targeted ...
ORGANISM(S): Drosophila melanogaster 
2007-10-02 | E-GEOD-8296 | biostudies-arrayexpress
TranscriptomicsChromatin IP of POF, HP1 and H3K9ac and transcript profiling in S2 cells and salivary glands
Two chromosome-targeting and gene regulatory systems are present in Drosophila melanogaster. The male X-chromosome is targeted by the male-specific lethal complex believed to mediate the two-fold up-regulation of the X-linked genes. The highly heterochromatic 4th chromosome is specifically targeted ...
ORGANISM(S): Drosophila melanogaster 
2007-10-02 | E-GEOD-8301 | biostudies-arrayexpress
GenomicsKlebsiella oxytoca HP1
Klebsiella oxytoca HP1 Genome sequencing
PRJNA173458 | ENA
TranscriptomicsHP1 is involved in regulating the global impact of DNA methylation on alternative splicing
The global impact of DNA methylation on alternative splicing is largely unknown. Using a genome-wide approach in wild-type and methylation-deficient embryonic stem cells, we found that DNA methylation can act both as an enhancer and as a silencer of splicing, and affects the splicing of more than 20...
ORGANISM(S): Mus musculus 
2015-03-08 | E-GEOD-64910 | biostudies-arrayexpress
ProteomicsProteomic profiling of PTMs at HP1 protein
The levels of phosphorylated HP1beta peptide forms in HeLa cells after irradiation and SAHA treatment were examined.
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD014802 | Pride
Hp1 protein Hela cells Irradiation Hdac inhibitor Human 
GenomicsEnsifer adhaerens strain:HP1
Ensifer adhaerens strain:HP1 Genome sequencing and assembly
PRJNA549840 | ENA
ProteomicsThe HP1 protein interactome of mouse embryonic stem cells
The family of Heterochromatin Protein 1 (HP1) consists of highly conserved proteins, which have important functions in the nucleus of eukaryotic cells. In mammals there are three HP1 paralogs: HP1(alpha), Hp1(beta), and Hp1(gamma)They are encoded by the Cbx5, Cbx1, and Cbx3 genes, respectively. Hp1 ...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-22 | PXD006226 | Pride
Lc-orbitrap fusion Mouse es-cells Tandem purification Chd4 Maxquant. Hp1 Cbx3 Adnp Cbx1 Hp1 Flag-avi-tag Cbx5 Hp1 
GenomicsHP1 resquencing
HP1 resequencing
PRJEB9930 | ENA
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