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GenomicsZFHX4 and CHD4 ChIP sequencing in glioblastoma tumor initiating cells
Glioblastomas (GBM) harbor subpopulations of therapy-resistant tumor initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397-kDa transcriptio...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-52419 | biostudies-arrayexpress
ProteomicsDefining the interactome of CHD4 in fusion-positive rhabdomyosarcoma
The goal of this study was to explore in detail how the chromatin remodeler and NuRD subunit CHD4 controls the oncogenic signature of the tumor driver and fusion protein PAX3-FOXO1 in fusion-positive rhabdomyosarcoma. To this aim, we defined the interactome of CHD4 by LC-MS, identified its location ...
ORGANISM(S): Homo sapiens (Human) 
2020-08-11 | PXD015231 | Pride
Nurd Rh4 Alveolar rhabdomyosarcoma Chd4 
ProteomicsA regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool
Maintenance and self-renewal of the spermatogonial stem cell (SSC) population is the cornerstone of male fertility. In this manuscript we have identified a key role for the nucleosome remodelling protein Chromodomain Helicase DNA binding protein 4 (CHD4) in regulating SSC function. Gene expression a...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-17 | PXD022066 | Pride
Spermatogonial stem cell Chd4 Mi-2β Self-renewal 
ProteomicsThe modulation of CHD4 nucleosome remodelling activity by auxiliary domains suggests unifies mechanistic aspects of chromatin remodelling across enzyme families
We determine the impact of auxiliary domains on the nucleosome sliding activity of CHD4. This dataset comprises the crosslinking mass spectrometry data we reported.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033633 | Pride
Xlms Chd4 Nucleosome remodelling Nurd Crosslinking 
TranscriptomicsExpression data from glioblastoma cells after ZFHX4 or CHD4 suppression.
ZFHX4 and CHD4 suppression independently shift tumor initiating cells out of a stem like state and toward a differentiated morphology. After gene suppression via transduction of a lentivirally mediated shRNA construct, RNA was extracted 3 and 5 days later and was hybridized on Affymetrix microarrays...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-52363 | biostudies-arrayexpress
TranscriptomicsRNA-seq data of mouse embryonic stem cells treated with auxin for CHD4 depletion against untreated control
This study investigates the role of the chromatin remodeller CHD4 in regulating gene expression. CHD4 was tagged with a mini-AID degron to enable auxin-inducible degradation. RNA-seq was performed at multiple time-points (1, 2, 4 and 24 hours) following auxin treatment to capture changes in gene exp...
ORGANISM(S): Mus musculus 
2026-01-15 | E-MTAB-15102 | biostudies-arrayexpress
TranscriptomicsATAC-seq data of mouse embryonic stem cells treated with auxin for CHD4 depletion against untreated control
This study investigates the role of the chromatin remodeller CHD4 in regulating chromatin accessibility. CHD4 was tagged with a mini-AID degron to enable auxin-inducible degradation. ATAC-seq was performed at multiple time-points (30 minutes, 1 hour, and 4 hours) following auxin treatment to capture...
ORGANISM(S): Mus musculus 
2026-01-15 | E-MTAB-15037 | biostudies-arrayexpress
TranscriptomicsNascent RNA-seq data of mouse embryonic stem cells treated with auxin for CHD4 depletion against untreated control
This study investigates the role of the chromatin remodeller CHD4 in regulating gene expression. CHD4 was tagged with a mini-AID degron to enable auxin-inducible degradation. RNA-seq of nascent transcripts was performed at multiple time-points (1, 2, 4 and 24 hours) following auxin treatment to capt...
ORGANISM(S): Mus musculus 
2026-01-15 | E-MTAB-15127 | biostudies-arrayexpress
GenomicsTranscriptome of E18.5 CHD4-M195I mouse hearts
Transcriptome of E18.5 CHD4-M195I mouse hearts
PRJNA952639 | ENA
Proteomicsbeta 1 integrin signaling governs necroptosis via the chromatin remodeling factor CHD4
Fibrosis, characterized by sustained activation of myofibroblasts and excessive extracellular matrix (ECM) deposition, is known to be associated with chronic inflammation. RIPK3, a key kinase mediating TNF-driven necroptosis signaling, is upregulated in fibrosis and contributes to the TNF-mediated i...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-30 | PXD041505 | Pride
Ripk3 Necroptosis Integrin Inflammation Chd4 Fibrosis 
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