Sort   by:  
 Page size 
TranscriptomicsA retrotransposon-driven Dicer variant enhances endogenous RNAi in mouse oocytes
Mammals have one Dicer gene required for biogenesis of small RNAs in microRNA (miRNA) and RNA interference (RNAi) pathways. Yet, endogenous RNAi is highly active in oocytes but not in somatic cells. Here, we provide a mechanistical explanation for high RNAi activity in mouse oocytes. The main Dicer ...
ORGANISM(S): Mus musculus 
2013-11-07 | E-GEOD-41207 | biostudies-arrayexpress
ProteomicsHuman LINE-1 ORF1p complex LC-MS/MS
Host proteins regulate LINE-1 (L1) retrotransposition. Here, we use immunoprecipitation followed by liquid chromatography-tandem mass spectrometry to identify proteins that associate with the L1 ORF1-encoded protein (ORF1p) in ribonucleoprotein particles.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038851 | Pride
Human Retrotransposon Line-1 
GenomicsEffect of upregulation of LINE-1 retrotransposon on translation in the mouse testis
Effect of upregulation of LINE-1 retrotransposon on translation in the mouse testis
PRJNA922045 | ENA
GenomicsHigh-Throughput LINE-1 Retrotransposon Discovery in Humans

The aim of this study is to discover LINE-1 (L1) insertion sites present in humans that are absent from the reference genome sequence. We use the distinguishing nucleotide characteristics of human-specific L1 elements to resequence the L1 3' flanking regions thus locating the L1 insertion s...

phs000273.v1.p1 | EGA
GenomicsIdentification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease
Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease
PRJNA1022033 | ENA
UnknownAssessment of genetic variation for the LINE-1 retrotransposon from next generation sequence data.
Not available
S-EPMC2967742 | biostudies-literature
TranscriptomicsEffect of upregulation of LINE-1 retrotransposon on translation in the mouse testis
We used piRNA-deficient Maelstrom (Mael) knockout mice to investigate the effect of LINE-1 retrotransposon upregulation on translation efficiency (TE) in the germline. We collected Mael+/- and Mael-/- testes at postnatal day 16 (P16), when LINE-1 upregulation in Mael-/- spermatocytes is manifest, an...
ORGANISM(S): Mus musculus 
2023-05-25 | GSE222415 | GEO
UnknownMethod of targeted bisulfite massive parallel sequencing of the human LINE-1 retrotransposon promoter.
Not available
S-EPMC8374674 | biostudies-literature
ProteomicsSelective identification of epigenetic regulators at methylated genomic sites
We applied SelectID coupled with the ultra-sensitive micro-DIA approach to enrich the associated proteins of Chromosome 9 satellite region and methylated LINE-1 elements.
ORGANISM(S): Homo Sapiens 
2025-03-08 | PXD061627 |
TranscriptomicsThe TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline
We identify small RNA partners of Mili from 14 dpp testes of Tdrd9-/- and Tdrd9+/- mice. Two technical replicates of the same library are indicated as replicate 1 and 2. Examination of differences in Mili-associated RNAs in 14 dpp testes of Tdrd9-/- and Tdrd9+/- mice
ORGANISM(S): Mus musculus 
2010-01-06 | E-GEOD-18825 | biostudies-arrayexpress
Sort   by:  
 Page size