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Proteomics53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ
53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination, and reduced fidelity of long...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-26 | PXD009650 | Pride
Rev7 shieldin 
Unknown53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.
Not available
S-EPMC6989217 | biostudies-literature
UnknownStructural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair.
Not available
S-EPMC6952594 | biostudies-literature
ProteomicsMAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair
MAD2L2 (also known as REV7) functions in a diverse range of processes. It facilitates DNA lesion bypass through translesion synthesis (TLS), aids in interstrand crosslink repair and contributes to timely mitotic progression. Moreover, MAD2L2 plays an important role in DNA repair at DNA double strand...
ORGANISM(S): Homo sapiens (Human) 
2021-09-21 | PXD026912 | Pride
Mad2l2 Trip13 Dna repair Shieldin Nhej 
UnknownShieldin complex assembly kinetics and DNA binding by SHLD3.
Not available
S-EPMC10082759 | biostudies-literature
UnknownMolecular basis for assembly of the shieldin complex and its implications for NHEJ.
Not available
S-EPMC7181697 | biostudies-literature
UnknownMolecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex.
Not available
S-EPMC7923543 | biostudies-literature
UnknownREV7: Jack of many trades.
Not available
S-EPMC7611290 | biostudies-literature
UnknownDisassembly of the Shieldin Complex by TRIP13.
Not available
S-EPMC7480811 | biostudies-literature
UnknownThe shieldin complex mediates 53BP1-dependent DNA repair.
Not available
S-EPMC6141009 | biostudies-literature
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