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ProteomicsCharacterization of the O-Glycoproteome of Prevotella intermedia
Prevotella intermedia is a Gram-negative bacterium belonging to the Bacteroidetes phylum and is notably linked to periodontitis. Several other species within this phylum have been reported to possess the general O-glycosylation system, and the O-glycoproteome has been well characterized in Tannerell...
ORGANISM(S): Prevotella intermedia ATCC 25611 = DSM 20706 
2024-02-14 | PXD047143 | Pride
Outer membrane vesicles O-glycosylation Bacteroidetes Type ix secretion system 
ProteomicsNear atomic structure of the PorKN rings, disulfide bonded to PorG and bound to Attachment Complexes, provides mechanistic insights into the type IX secretion system: CE and Co-immunoprecipitation
The Type IX Secretion System exports proteins across the outer membrane (OM) of bacteria in the Bacteroidota phylum, however, the mechanistic details remain unknown. Here, we present a ~3.5Å cryo-EM structure of the periplasmic rings comprising 32-33 subunits each of PorK and PorN. Additionally, we ...
ORGANISM(S): Porphyromonas gingivalis ATCC 33277 Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 
2025-07-21 | PXD062825 | Pride
Porphyromonas gingivalis Type ix secretion system 
TranscriptomicsPorphyromonas gingivalis 33277 wild-type vs Fur orthologue Har isogenic mutant ECR455
Porphyromonas gingivalis is a major pathogen associated with the microbial biofilm-mediated disease chronic periodontitis. P. gingivalis has an obligate requirement for iron and protoporphyrin IX which it satisfies by transporting heme and iron liberated from the human host. The level of cellular ir...
ORGANISM(S): Porphyromonas gingivalis ATCC 33277 
2015-04-01 | E-GEOD-37099 | biostudies-arrayexpress
ProteomicsNear atomic structure of the PorKN rings, disulfie bonded to PorG and bound to the Attachment Complexes, provide mechanistic insights into the Type IX Secretion System
The Type IX Secretion System exports proteins across the outer membrane (OM) of bacteria in the Bacteroidota phylum, however, the mechanistic details remain unknown. Here, we present a 3.5 angstrom cryo-EM structure of the periplasmic rings comprising 32-33 subunits each of PorK and PorN. Additional...
ORGANISM(S): Porphyromonas gingivalis W50 
2025-08-25 | PXD062800 | Pride
Type 9 secretion system Porphyromonas gingivalis 
ProteomicsC-terminal glycosylation of type IX secretion system cargo proteins in Prevotella intermedia bearing both short and long secretion signals
Prevotella intermedia is a Gram-negative bacterium that is notably linked to periodontitis and acute necrotizing ulcerative gingivitis. P. intermedia is known to utilise the T9SS to secrete and anchor virulence factors to the cell surface, presumably via C-terminal modification of the cargo protein ...
ORGANISM(S): Prevotella intermedia ATCC 25611 = DSM 20706 
2025-05-07 | PXD057272 | Pride
Glycosylation Secretion signal Surface proteins Prevotella intermedia Alaninamide Mass spectrometry Protein secretion 
TranscriptomicsPorphyromonas gingivalis W50 Heme-excess vs Heme-limitation
Transcription profiling of P. gingivalis W50 grown in continuous culture under conditions of heme-excess and heme-limitation. Reference design (using Cy5 labelled genomic DNA as the reference) to compare two conditions: heme-excess vs heme-limitation. Three samples for each condition, independently...
ORGANISM(S): Porphyromonas gingivalis 
2010-05-16 | E-GEOD-13375 | biostudies-arrayexpress
ProteomicsThe pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo
Objective: In vivo studies in humans and mice have implicated the pseudokinase Tribbles 3 (TRIB3) in various aspects of energy metabolism. Whilst cell-based studies indicate a role for TRIB3 in adipocyte differentiation and function, it is unclear if and how these cellular functions may contribute t...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-26 | PXD046703 | Pride
Tribbles  adipocyte  omics analyses  metabolism 
TranscriptomicsTranscription profiling of Porphyromonas gingivalis wild type and mutant PG1432::ermF to identify genes which have their expression influenced by PG1432
The aim of this experiment is to ascertain which genes have their expression influenced by PG1432. PG1432 encodes a putative sensor histidine kinase which is part of two component signal transduction that was highly up-regulated in P. gingivalis mature biofilm cells. PG1432 was disrupted in P. gingi...
ORGANISM(S): Porphyromonas gingivalis 
2010-01-11 | E-TABM-546 | biostudies-arrayexpress
TranscriptomicsTreponema denticola gene expression during co-culture with Porphyromonas gingivalis
Porphyromonas gingivalis and Treponema denticola are periodontalpathogens that are associated with the severity and progression of periodontal diseases. this study investigates the gene expression of Treponema denticola during co-culture with Porphyromonas gingivalis.
ORGANISM(S): Treponema denticola 
2014-03-31 | E-MTAB-2257 | biostudies-arrayexpress
TranscriptomicsPorphyromonas gingivalis gene expression during co-culture with Treponema denticola
Porphyromonas gingivalis and Treponema denticola are periodontalpathogens that are associated with the severity and progression of periodontal diseases. This study investigates the gene expression of Porphyromonas gingivalis during co-culture with Treponema denticola
ORGANISM(S): Porphyromonas gingivalis 
2014-03-31 | E-MTAB-2214 | biostudies-arrayexpress
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