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ProteomicsProtein and Signaling Pathway Responses to rhIL-6 Intervention before Lobaplatin Treatment in Osteosarcoma Cells using LC-MS/MS
Lobaplatin is a third-generation platinum-based antineoplastic agent and is widely used for osteosarcoma treatment before and after tumor removal. However, treatment failure often results from lobaplatin drug resistance. In our study, we found that SaOS-2 and SOSP-9607 osteosarcoma cells became less...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD021564 | Pride
Human Lobaplatin Rhil-6 Osteosarcoma Liquid chromatography-tandem mass spectrometry 
ProteomicsProtein and Signaling Pathway Responses to rhIL-6 Intervention before Lobaplatin Treatment in Osteosarcoma Cells using Quantitative Phosphoproteome Analysis
IL-6 plays a pivotal role in the process of drug resistance to kinds of chemotherapeutics including lobaplatin. However, the underlying changes of phosphoproteins and related signaling pathways in the posttranslational modification level is still uncover. In our study, a quantitative phosphoproteome...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025970 | Pride
Human Phosphoproteome analysis Lobaplatin Il-6 Osteosarcoma 
UnknownQuantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells.
Not available
S-EPMC8557500 | biostudies-literature
UnknownProtein and Signaling Pathway Responses to rhIL-6 Intervention Before Lobaplatin Treatment in Osteosarcoma Cells.
Not available
S-EPMC8006349 | biostudies-literature
TranscriptomicsmicroRNA expression signature of monocyte-derived dendritic cells (DCs) from peripheral blood mononuclear cells (PBMCs)
In order to detect the microRNA expression profile of in vitro generated dendritic cells , purified monocytes from PBMCs were used as dendritic cell (DCs) precursors and were cultured in medium with cocktail for differentiation and maturation to immature dendritic cells (iDCs) and mature dendritic c...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-15036 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of monocyte-derived dendritic cells (DCs) from peripheral blood mononuclear cells (PBMCs)
In order to detect the gene expression profile of in vitro generated dendritic cells , purified monocytes from PBMCs were used as dendritic cell (DCs) precursors and were cultured in medium with cocktail for differentiation and maturation to immature dendritic cells (iDCs) and mature dendritic cells...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-15075 | biostudies-arrayexpress
UnknownProtein‑ and growth‑modulatory effects of carcinoma‑associated fibroblasts on breast cancer cells: Role of interleukin‑6.
Not available
S-EPMC6910226 | biostudies-literature
UnknownTofacitinib Inhibits STAT Phosphorylation and Matrix Metalloproteinase-3, -9 and -13 Production by C28/I2 Human Juvenile Chondrocytes
Not available
S-EPMC9547596 | biostudies-literature
UnknownIL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC).
Not available
S-EPMC8404457 | biostudies-literature
UnknownEndogenous bone morphogenetic protein 2 plays a role in vascular smooth muscle cell calcification induced by interleukin 6 in vitro.
Not available
S-EPMC5815263 | biostudies-literature
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