Rho signaling - OmicsDI

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2006 (2)

UNIPROT ID/AC

10090.ENSMUSP00000078339 (2)
10090.ENSMUSP00000079727 (2)
10116.ENSRNOP00000008094 (2)
10116.ENSRNOP00000038745 (2)
10116.ENSRNOP00000046711 (2)
10116.ENSRNOP00000054601 (2)
10116.ENSRNOP00000059382 (2)
10116.ENSRNOP00000060273 (2)
10116.ENSRNOP00000066778 (2)
10116.ENSRNOP00000067409 (2)
1433S_MOUSE (2)
2ABA_MOUSE (2)
3HIDH_MOUSE (2)
41_CHICK (2)
9031.ENSGALP00000001352 (2)
9031.ENSGALP00000005115 (2)
9031.ENSGALP00000005340 (2)
9031.ENSGALP00000005497 (2)
9031.ENSGALP00000006909 (2)
9031.ENSGALP00000007662 (2)
9031.ENSGALP00000007667 (2)
9031.ENSGALP00000008279 (2)
9031.ENSGALP00000021815 (2)
9031.ENSGALP00000026707 (2)
9031.ENSGALP00000027141 (2)
9031.ENSGALP00000039755 (2)
9031.ENSGALP00000040189 (2)
9031.ENSGALP00000041846 (2)
9031.ENSGALP00000042511 (2)
9031.ENSGALP00000043018 (2)

ENSEMBL ID

ENSG00000170477 (1)
ENSG00000204131 (1)

CHEBI ID

CHEBI:18186 (3)
CHEBI:16436 (3)
CHEBI:75632 (2)
CHEBI:566519 (2)
CHEBI:18125 (2)
CHEBI:64681 (2)
CHEBI:28918 (2)
CHEBI:16811 (2)
CHEBI:10136 (2)
CHEBI:16077 (2)
CHEBI:28044 (2)
CHEBI:28790 (2)
CHEBI:17650 (2)
CHEBI:17385 (2)
CHEBI:17597 (2)
CHEBI:18066 (2)
CHEBI:17509 (2)
CHEBI:73024 (2)
CHEBI:16750 (2)
CHEBI:16761 (2)
CHEBI:16680 (2)
CHEBI:16347 (2)
CHEBI:27732 (2)
CHEBI:27897 (2)
CHEBI:17596 (2)
CHEBI:28177 (2)
CHEBI:235347 (1)
CHEBI:235346 (1)
CHEBI:232995 (1)
CHEBI:233763 (1)

Metabolite Name

Methionine (3)
L-Cystathionine (2)
2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine (2)
Dimethylglycine (2)
FAD (2)
Thymine (2)
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Deoxycholic acid (2)
Citric acid (2)
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Alanine (2)
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L-Tyrosine (2)
Trans-O-Coumaric Acid (1)
Trans-M-Coumaric Acid (1)
S-equol (1)
Quercetin-7-O-B-D-Glucuronide (1)
Kaempferol-3-O-Glucuronide (1)
Homoprotocatechuic Acid (1)
Genistein-7-Sulfate (1)
Genistein-7-B-D-Glucuronide (1)
Daidzein-7-B-D-Glucuronide (1)
Caffeic Acid-3-B-D-Glucuronide (1)
3,5-Dimethoxy-4-Hydroxyphenylacetic Acid (1)
(-)-Epicatechin Gallate (1)
Neohesperidin Dihydrochalcone (1)
(-)-Epigallocatechin Gallate (1)
BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE (1)

First Public Date

2026 (40)
2024 (31)
2025 (26)
2014 (22)
2023 (15)
2021 (14)
2019 (13)
2022 (12)
2020 (12)
2017 (11)
2018 (6)
2015 (3)
2016 (2)
2013 (1)

Modelling Approach

Ordinary differential equation model (1)

Lab affiliation

Max Delbrueck Center for Molecular Medicine (2)
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen (2)
1 Department of Biological Sciences, College of Arts and Sciences, University of North Texas, Denton, TX 2 Advanced Environmental Research Institute (AERI), University of North Texas, Denton, TX (1)
Biological Mass Spectrometry Lab, Department of Translational Medicine (DiMeT),Center for Translational Research on Autoimmune & Allergic Diseases - CAAD, University of Piemonte Orientale Corso Trieste 15/A, 28100, Novara, Italy. (1)
Brown University (1)
CRUK - Beatson Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)
CRUK Beatson Institute (1)
Centre de Recherches en Cancérologie de Toulouse; INSERM U1037, team 17 PI3K isoforms, signalling and cancerogenesis (1)
Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide SA 5000, Australia (1)
Chair of Proteomics and Bioanalytics, Technical University of Munich, Germany (1)
Clinical Proteomics Laboratory, Institute of Chemistry, UPD (1)
Copenhagen University (1)
Cornell University, Ithaca, NY, USA (1)
Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 5C1, Canada (1)
Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy (1)
Department of Chemistry, Chair of Organic Chemistry II, Technical University of Munich, Germany (1)
Department of Gametes and Embryo Biology, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, 10-748, Poland (1)
Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, QC, Canada (1)
Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon 34134, Korea (1)
Department of Pathogen Biology and Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China (1)
Department of Pathogen Biology and Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. School of Pharmaceutical Science and Technology, Health Science Platform, Tianjin University, Tianjin, 300072, China (1)
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI (1)
Department of Physical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland (1)
Departments of Genetics and Biochemistry, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA (1)
Direktor Institut für Neuroanatomie und Zellbiologie Medizinische Hochschule Hannover (MHH) (1)
Dr. Jörn Dengjel Prof. for Biochemistry and Cell Biology Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 E joern.dengjel@unifr.ch F +41 26 300 9741 (1)
Group Leader, Proteomics of Cellular Signaling, Luxembourg Institute of Health (1)
Head Proteomics Group, Leiden University Medical Center, Center for Proteomics and Metabolomics, PO Box 9600, Postal zone P1-Q, 2300 RC Leiden, The Netherlands (1)
Indiana University School of Medicine, USA (1)
Institute of Biomedicine, and Medicity Research Laboratories, University of Turku, Turku, Finland; Turku Bioscience Centre, University of Turku, and Åbo Akademi University, Turku, Finland (1)

IsPrivate

False (1)

Classification

fungi (1)
protozoa (1)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (182)
RNA-seq of coding RNA (27)
RIP-seq (6)
ChIP-seq (6)
RNA-seq of non coding RNA (5)
Unknown experiment type (3)
ChIP-chip by array (3)
Comparative genomic hybridization by array (3)
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ChIP-chip by tiling array (2)
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RNA-seq of coding RNA from single cells (2)
Methylation profiling by high throughput sequencing (2)
Human - High-throughput sequencing (1)
Cell line - One-color microarray (1)
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CUT&RUN (1)

Release Date

2022 (175)
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2020 (159)
2014 (157)
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2016 (141)
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2006 (32)
2005 (23)
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2004 (12)
2003 (12)
2002 (10)
2000 (6)
2001 (5)
1999 (4)
1998 (4)
1997 (1)

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Transcription profiling of mouse primary keratinocytes expressing Rho/CRIK to study the impact of Rho signaling pathway on gene expression.

Rho GTPases integrate control of cell structure and adhesion with downstream signaling events. In keratinocytes, RhoA is activated at early times of differentiation and plays an essential function in establishment of cell–cell adhesion. We report here that, surprisingly, Rho signaling suppresses dow...

ORGANISM(S): Mus musculus

2007-09-07 | E-GEOD-3162 | biostudies-arrayexpress

Targeted metabolomic profiling of retinas from WT and Rho-Cre/Mfn1flx/flx/Mfn2flx/flx mice

Mitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these structures include elongated mitochondria in the inner segments and a distinct, large, circular mitochondrion in each ...

2026-03-12 | MTBLS12512 | MetaboLights

Systems Modeling of the Rho Signaling Network

Describing the architecture of robust, nonlinear cell signaling networks is essential to gain a predictive understanding of cellular behavior. The structure of the Drosophila Rho-signaling network, comprised of Rho-family GTPases, RhoGTP Exchange Factors (RhoGEFs), and RhoGTPase Activating Proteins...

ORGANISM(S): Drosophila melanogaster

2012-12-31 | E-GEOD-18307 | biostudies-arrayexpress

Localized Rho GTPase Activation Regulates RNA Dynamics and Compartmentalization in Tumor Cell Protrusions

mRNA trafficking and local protein translation are associated with protrusive cellular domains, such as neuronal growth cones, and deregulated control of protein translation is associated with tumor malignancy. We show here that activated RhoA, but not Rac1, is enriched in pseudopodia of MSV-MDCK-IN...

ORGANISM(S): Canis lupus familiaris

2010-05-18 | E-GEOD-13253 | biostudies-arrayexpress

Transcription profiling of human monocyte derived dendritic cells treated with DC-SIGN initiates an immature dendritic cell phenotype triggering Rho activation that is utilised by HIV-1

DC-SIGN is a C-type lectin expressed by dendritic cells (DCs) that binds HIV-1, sequestering it within multivesicular bodies to facilitate transmission to CD4+ T cells. Here we characterize the molecular basis of signalling through DC-SIGN by large-scale gene expression profiling and phosphoproteome...

ORGANISM(S): Homo sapiens

2008-06-14 | E-GEOD-6090 | biostudies-arrayexpress

Ota2015 - Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs (GDI integrated)

This is a ordinary differential equation mathematical model describing the Rho GTPase cycle in which Rho GDP-dissociation inhibitors (RhoGDIs) inhibit the regulatory activities of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) by interacting with them directly as we...

2024-09-02 | BIOMD0000000899 | BioModels

Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights

Bistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.

Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2017-03-29 | MSV000080751 | MassIVE

Constitutively active RhoA (RhoAV14) expression and regulation of acqeous humor outflow dynamics

Impaired drainage of aqueous humor through the trabecular meshwork (TM) culminating in increased intraocular pressure is a major risk factor for glaucoma, a leading cause of blindness worldwide. Regulation of aqueous humor drainage through the TM, however, is poorly understood. The role of RhoA GTPa...

ORGANISM(S): Homo sapiens

2010-05-19 | E-GEOD-9288 | biostudies-arrayexpress

Modeling and modulation of RHO signaling in human iPSC-derived retinal organoids from patients with RHO-CNV

PRJNA1028965 | ENA

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