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ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
ProteomicsRhoA inhibitor treatment of spinal cord injury: Deep inside mechanism understanding for a better use
The present study shows by in vivo experiments, the impact of RhoA inhibitor treatment using a functionalized alginate scaffold and the beneficial results at the early stage by increasing neurites outgrowth and synaptic contact. However, 7 days after treatment a plateau is obtained in BBB score. We ...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-07-28 | PXD004639 | Pride
Spinal cord lesion Cd32 Anti-gfap Rhoa inhibitor Proteomic Transcriptomic factors In vivo studies Functionalized alginate Growth cone Immunoglobulins Neurites outgrowth 
TranscriptomicsRHOA inactivation enhances Wnt signaling and promotes colorectal cancer
Microarray transcriptomic analysis of formalin-fixed, paraffin-embedded small intestinal tumors from control (Apcmin/+;Vil-Cre-/-;RhoADN/-) and DN-RhoA (Apcmin/+;Vil-CreTG/-;RhoADN/-) mice.
ORGANISM(S): Mus musculus 
2014-11-21 | E-MTAB-2981 | biostudies-arrayexpress
ProteomicsIdentification of novel RHOA interacting patners
RHO subfamily of small GTPases comprise highly conserved family members RHOA, RHOB, and RHOC which cycle between GTP-bound 'active' and GDP-bound 'inactive' states. In the active form, RHO proteins interact with a variety of downstream effector proteins, controlling their activity and function. Many...
ORGANISM(S): Homo sapiens (Human) 
2016-11-01 | PXD004934 | Pride
Silac  lc-ms  protein-protein interactions  rhoa 
TranscriptomicsThe flavonoid glycoside isoquercitrin promotes neurite network formation through a down regulation of RhoA activity
We observed extensive neurite formation in NG108-15 cells cultured in the presence of the flavonoid, isoquercitrin. To help determine the mechanism of neuritogenesis, microarray analysis was performed on samples treated with 40 uM isoquercitrin for 24 hrs.
ORGANISM(S): Mus musculus 
2012-10-19 | E-MEXP-3418 | biostudies-arrayexpress
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD003213 | Pride
Mathematical modelling Rhoa Cell motility Rac1 Bistable switches Pak inhibition 
ProteomicsProteomic analysis of adult CNS from Rhoa cKOs and CTRs mice
Oligodendrocyte differentiation and subsequent myelination rely on strict regulatory mechanisms and molecules. Here we aimed at understanding the role of the Rho GTPase RhoA during oligodendrocyte differentiation and myelination in vivo. Using a conditional cell-specific ablation of Rhoa (Rhoa fl/fl...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-05 | PXD055052 | Pride
Rhoa Optic nerve Oligodendrocyte Rho gtpase Mouse Lc-ms/ms 
GenomicsTargeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells [scRNA-seq]
Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells [scRNA-seq]
PRJNA1124165 | ENA
GenomicsTargeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells [bulk ATAC-seq]
Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells [bulk ATAC-seq]
PRJNA979159 | ENA
GenomicsTargeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells [bulk RNA-seq]
Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells [bulk RNA-seq]
PRJNA979157 | ENA
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