Sort   by:  
 Page size 
ProteomicsAffinity Purification Mass Spectrometry of protein protein interactors with alternatively-spliced Uromodulin
We identified an alternatively spliced UMOD which is uniquely localized intracellularly. This intracellular isoform enhanced mitochondrial function. To understand its molecular mechanism, we performed affinity-purification coupled to mass spectrometry using MDCK cell lysate expressing UMOD variant. ...
ORGANISM(S): Canis Lupus Familiaris (ncbitaxon:9615) Homo Sapiens (ncbitaxon:9606) 
2024-03-15 | MSV000094329 | MassIVE
UnknownImpact of Complete Revascularization in the ISCHEMIA Trial.

Background

Anatomic complete revascularization (ACR) and functional complete revascularization (FCR) have been associated with reduced death and myocardial infarction (MI) in some prior studies. The impact of complete revascularization (CR) in patients undergoing an invasive (INV) compared w...
S-EPMC10529674 | biostudies-literature
UnknownHigher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants.

Background

Limited data suggest that higher hemoglobin thresholds for red-cell transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants with anemia.

Methods

We performed an open, multicenter trial in which infants with a birth weight of 1000 g or le...
S-EPMC8487591 | biostudies-literature
UnknownHydrocortisone to Improve Survival without Bronchopulmonary Dysplasia.

Background

Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development. Whether hydrocortisone treatment after the second postnatal week can improve survival without bronchopulmonary dysplasi...
S-EPMC9107291 | biostudies-literature
UnknownInterplay of Immunosuppression and Immunotherapy Among Patients With Cancer and COVID-19.

Importance

Cytokine storm due to COVID-19 can cause high morbidity and mortality and may be more common in patients with cancer treated with immunotherapy (IO) due to immune system activation.

Objective

To determine the association of baseline immunosuppression and/or IO-based therapi...
S-EPMC9634600 | biostudies-literature
UnknownThe bii4africa dataset of faunal and floral population intactness estimates across Africa's major land uses.
Sub-Saharan Africa is under-represented in global biodiversity datasets, particularly regarding the impact of land use on species' population abundances. Drawing on recent advances in expert elicitation to ensure data consistency, 200 experts were convened using a modified-Delphi process to estimate...
S-EPMC10861571 | biostudies-literature
UnknownThe cost-effectiveness of wound-edge protection devices compared to standard care in reducing surgical site infection after laparotomy: an economic evaluation alongside the ROSSINI trial.

Background

Wound-edge protection devices (WEPDs) have been used in surgery for more than 40 years to reduce surgical site infection (SSI). No economic evaluation of WEPDs against any comparator has ever been conducted. The aim of the paper was to assess whether WEPDs are cost-effective in re...
S-EPMC3991705 | biostudies-literature
UnknownExploratory analysis of the effect of intravitreal ranibizumab or triamcinolone on worsening of diabetic retinopathy in a randomized clinical trial.

Importance

The standard care for proliferative diabetic retinopathy (PDR) usually is panretinal photocoagulation, an inherently destructive treatment that can cause iatrogenic vision loss. Therefore, evaluating the effects of therapies for diabetic macular edema on development or worsening o...
S-EPMC4162127 | biostudies-literature
UnknownRandomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema.

Objective

Evaluate intravitreal 0.5 mg ranibizumab or 4 mg triamcinolone combined with focal/grid laser compared with focal/grid laser alone for treatment of diabetic macular edema (DME).

Design

Multicenter, randomized clinical trial.

Participants

A total of 854 study eyes of 6...
S-EPMC2937272 | biostudies-literature
UnknownClopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.

Background

Combination antiplatelet therapy with clopidogrel and aspirin may reduce the rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient ischemic attack (TIA). A trial of combination antiplatelet therapy in a Chinese population has shown a reducti...
S-EPMC6193486 | biostudies-literature
Sort   by:  
 Page size