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ProteomicsFOXE3 Contributes to Peters Anomaly through Transcriptional Regulation of an Autophagy Associated Protein termed DNAJB1
FOXE3 is a lens specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncate...
ORGANISM(S): Homo sapiens (Human) 
2016-03-31 | PXD003436 | Pride
Foxe3 Peters anomaly Dnajb1 
ProteomicsProteome Profiling of PBMC-originated, iPSC-derived Lentoid Bodies at differentiation day 35
Differentiation of pluripotent stem cells into lentoid bodies is important for the understanding of the lens development and investigating the processes critical for lens morphogenesis. This Study was initiated to investigate a comprehensive proteome profiling of the peripheral blood mononuclear cel...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD009633 | Pride
Mass-spectrometry Ipsc-derived lentoid bodies Proteome Pbmc 
ProteomicsGeneration and Proteome Profiling of PBMC-originated, iPSCs-derived Corneal Endothelial Cells
Corneal endothelial cells (CECs) are critical to maintaining clarity of the cornea. This study was initiated to develop peripheral blood mononuclear cells (PBMC)-originated induced pluripotent stem cells (iPSCs)-derived CECs. We isolated PBMC and programmed the mononuclear cells to generate iPSCs. S...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD009142 | Pride
Mass-spectrometry Proteome Ipscs-derived corneal endothelial cells Pbmc 
ProteomicsThe indispensable role of autophagy in lens morphogenesis
FYVE and coiled-coil domain containing 1 (FYCO1) is expressed ubiquitously and is required for microtubule-dependent, plus-end-directed transport of autophagic vesicles. We previously reported the loss of function mutations in FYCO1 responsible for cataractogenesis with no other ocular and/or extra-...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD017001 | Pride
Mass-spectrometry H9 hesc-derived lentoid bodies Tmt Proteome 
ProteomicsCigarette smoke induces changes in the basement membrane proteins of the corneal endothelium
Proteome profiling was performed to investigate changes at a molecular level in the mouse corneal endothelium (CE) along with the basement membrane exposed to cigarette smoke (CS). Pregnant mice (gestation days 18-20) were placed in a whole-body exposure smoking chamber and a few days later pups wer...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020036 | Pride
Mass-spectrometry Corneal endothelium Basement membrane Proteome Cigarette smoke 
ProteomicsTranscriptome, proteome, and metabolome of lens fiber cells from mice exposed to cigarette smoke
We adopted an omics (transcriptome, proteome, and metabolome) approach to characterize the lens fiber cells extracted from control (CT) and cigarette smoke (CS) exposed mouse (C57BL/6) eyes. The eight pregnant female mice (gestation days 19-20) were placed in a whole-body exposure smoking chamber an...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD017414 | Pride
Mouse Metabolome Mass spectromtery Proteome Transcriptome 
ProteomicsTranscriptome, proteome, and metabolome of lens fiber cells from mice exposed to cigarette smoke
We adopted an omics (transcriptome, proteome, and metabolome) approach to characterize the lens fiber cells extracted from control (CT) and cigarette smoke (CS) exposed mouse (C57BL/6) eyes. The eight pregnant female mice (gestation days 19-20) were placed in a whole-body exposure smoking chamber an...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD020421 | Pride
Mass-spectrometry Mouse lens fiber cells Tmt Proteome Cigarette smoke 
TranscriptomicsTranscriptome Profiling of Developing Murine Lens through RNA Sequencing
Purpose: Transcriptome is the entire repertoire of all transcripts present in a cell at any particular time. We undertook next-generation whole transcriptome sequencing approach to gain insight of the transcriptional landscape of the developing mouse lens. Methods: We ascertained mice lenses at six ...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-69221 | biostudies-arrayexpress
ProteomicsProteome of the Developing Murine Lens Through Mass Spectrometry
The proteome is a term used for the entire catalog of proteins present in a cell at any time. In here, we investigated the proteome of developing mouse lens through mass spectrometry-based protein sequencing. We extracted mouse lenses at six developmental time points, which included two embryonic (E...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-22 | PXD006381 | Pride
Mouse ocular lens Mass-spectrometry Proteome 
MetabolomicsThe role of FYCO1-dependent autophagy in lens fiber cell differentiation.

FYCO1 (FYVE and coiled-coil domain containing 1) is an adaptor protein, expressed ubiquitously and required for microtubule-dependent, plus-end-directed transport of macroautophagic/autophagic vesicles. We have previously shown that loss-of-function mutations in FYCO1 cause cataracts wit...

2024-03-24 | MTBLS206 | MetaboLights
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