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ProteomicsIdentification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT
Identification of the binding interface between HttExon1Q48 and the molecular chaperone DNAJB1. The proteins were incubated and cross-linked in vitro and the binding interface was mapped to the hinge region between CTDI and CTDII of DNAJB1 and the proline rich domain of HTTEXon1Q48.
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-10-15 | PXD031214 | Pride
Mass spectrometry Dnajb1 Htt Crosslinking 
ProteomicsThe oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma, a lethal disease lacking specific therapies. This study reports on the identification, characterization, and immunotherapeutic application of HLA-presented neoantigens specific for the DNAJB1-PRKAC...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD029882 | Pride
Cancer Hla ligands Mass spectrometry Fibrolamellar hepatocellular carcinoma Immunopeptidomics Fl-hcc 
ProteomicsFOXE3 Contributes to Peters Anomaly through Transcriptional Regulation of an Autophagy Associated Protein termed DNAJB1
FOXE3 is a lens specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncate...
ORGANISM(S): Homo sapiens (Human) 
2016-03-31 | PXD003436 | Pride
Foxe3 Peters anomaly Dnajb1 
ProteomicsIncreased activity of protein kinase A, even without DNAJB1, is sufficient to cause Fibrolamellar hepatocellular carcinoma
Most fibrolamellar carcinoma (FLC) is driven by a fusion of DNAJB1 and PRKACA, the catalytic subunit of protein kinase A (PKA). PKA holoenzyme activity is controlled through a regulatory protein (R) that both inhibits and localizes catalytic activity. An excess of regulatory subunits ensures PRKACA ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-17 | PXD043816 | Pride
Liver cancer Tumorigenesis Fusion oncoprotein Childhood cancer Adolescent and young adult cancer Protein kinase a Fibrolamellar carcinoma 
ProteomicsHSPA1A and DNAJB1 regulate NELF condensate reversibility to safeguard transcriptional recovery under heat stress
The negative elongation factor (NELF) is essential in establishing RNA Polymerase II (Pol II) pausing at promoter-proximal regions, providing a key regulatory checkpoint for precise gene expression control. In response to heat shock (HS) stress, NELF has been observed to form nuclear condensates, bu...
ORGANISM(S): Homo Sapiens 
PXD064175 |
ProteomicsCellular Protein Client Recovery by Human Hsp40s DNAJB1 and DNAJB8
We applied TMT-AP-MS to study protein clients between wild type and different mutations of DNAJB1 and DNJAB8 in HEK293T cells. We also applied heat to see how the interactome changes between different types of bait.
ORGANISM(S): Homo sapiens (Human) 
2022-03-28 | PXD030633 | Pride
Human Ap-ms Heat Hsp40 Dnjab8 Cross-linking 
GenomicsEffects of fibrolamellar carcinoma-associated DNAJB1-PRKACA in HEK293T cells
Effects of fibrolamellar carcinoma-associated DNAJB1-PRKACA in HEK293T cells
PRJNA679841 | ENA
GenomicsIncreased activity of protein kinase A, even without DNAJB1, is sufficient to cause Fibrolamellar hepatocellular carcinoma
Increased activity of protein kinase A, even without DNAJB1, is sufficient to cause Fibrolamellar hepatocellular carcinoma
PRJNA996178 | ENA
ProteomicsPresentation of DNAJB1-PRKACA fusion neoantigens by different HLA class I alleles
Fibrolamellar carcinoma (FLC) is a liver tumor with a high mortality burden and few treatment options. A promising therapeutic vulnerability in this disease is its highly conserved driver mutation: a gene fusion between DNAJB1 and PRKACA, which is expressed in virtually all FLC tumors and could be a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042316 | Pride
Fusion neoantigens Hla class i Cd8 t cell Dnajb1-prkaca Fibrolamellar carcinoma 
GenomicsSingle cell RNA-seq and TCR-seq of T cell responses against DNAJB1-PRKACA
Single cell RNA-seq and TCR-seq of T cell responses against DNAJB1-PRKACA
PRJNA865298 | ENA
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