Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a CAG trinucleotide repeat in the Huntingtin (HTT) gene, encoding a homopolymeric polyglutamine (polyQ) tract. Although mutant HTT (mHTT) protein is known to aggregate, the links between aggregation and neurotoxicity re...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)
Parkinson’s disease is the second most common neurodegenerative disease, currently without any disease modifying therapy. Although α-synuclein is causatively linked to Parkinson’s pathogenesis, the primary mechanism and subcellular localisation of early cytotoxicity as well as its most damaging...
