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TranscriptomicsMassively Parallel Sequencing Identifies the MicroRNA Transcriptome of Normal and Malignant Human B cells
Profiling of miRNA transcriptome in Human mature B cells from similar populations Profiling of miRNA transcriptome in Human Normal and Malignant B cells, 8 normal samples corresponding to Naïve, Germinal Center, Plasma and Memory B cells and 23 samples derived from B cell malignancy
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-15229 | biostudies-arrayexpress
TranscriptomicsDeep Sequencing of the Small RNA Transcriptome of Normal and Malignant Human B cells Identifies Hundreds of Novel MicroRNAs: microarray analysis
A role for microRNAs has been recognized in nearly every biological system examined thus far. A complete delineation of their role must be preceded by the identification of all microRNAs present in any system. We elucidated the complete small RNA transcriptome of normal and malignant B cells through...
ORGANISM(S): Homo sapiens 
2010-08-26 | E-GEOD-22895 | biostudies-arrayexpress
TranscriptomicsA Phase Two Randomised Controlled Trial of Belimumab in Kidney Transplant Recipients Demonstrates Comparable Safety, a Reduction in De Novo Antibody Production and an Increase in Regulatory B Cells.
There is an urgent unmet need in solid organ transplantation for immunotherapeutic strategies that target B cells and plasma cells, ideally without increasing infectious complications. We conducted a phase 2 double-blind randomised placebo-controlled trial to assess the safety and potential efficacy...
ORGANISM(S): Homo sapiens 
2018-06-11 | E-MTAB-5906 | biostudies-arrayexpress
TranscriptomicsExpression data from canine B-cell lymphomas
Pet dogs may provide a useful large-animal model of spontaneously occuring non-Hodgkin lymphoma, but complete molecular characterization is lacking. We used gene expression microarrays to molecularly characterize canine lymphoma, and found similarities between canine B-cell lymphoma and human diffus...
ORGANISM(S): Canis lupus familiaris 
2013-07-02 | E-GEOD-43664 | biostudies-arrayexpress
GenomicsGenetic and Functional Drivers of Diffuse Large B Cell Lymphoma
Diffuse large B cell lymphoma (DLBCL) is the most common hematologic malignancy and is characterized by a striking degree of heterogeneity. We enrolled a total of 1001 DLBCL patients and comprehensively defined the landscape of genetic mutations, copy number alterations and expression through whole-...
EGAS00001002606 | EGA
TranscriptomicsClassifying the Canine B-cell Lymphoma Cell line CLBL1
In 2013, Richards, et al. reported in Cancer Research that canine b-cell lymphomas could be subclassificed by gene expression profiling as ABC-like or GCB-like, similar to their human diffuse large B-cell lymphomas. This study, therefore, sought to classify the cell line CLBL1 as either GCB or ABC.
ORGANISM(S): Canis lupus familiaris 
2016-05-05 | GSE81110 | GEO
ProteomicsKinome profiling of diffuse large B-cell lymphoma cells in response to dasatinib
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, with at least one-third of its patients not responding to the current chemotherapy regimen, R-CHOP. By gene expression profiling, patients with DLBCL can be categorized into two clinically relevant subtypes: activated B-cell (ABC) DL...
ORGANISM(S): Homo sapiens (Human) 
2018-12-14 | PXD009380 | Pride
Lymphoma Cancer Dasatinib Lc-ms Kinome 
TranscriptomicsDeep Sequencing of the Small RNA Transcriptome of Normal and Malignant Human B cells Identifies Hundreds of Novel MicroRNAs
This SuperSeries is composed of the following subset Series: GSE15229: Massively Parallel Sequencing Identifies the MicroRNA Transcriptome of Normal and Malignant Human B cells GSE22895: Deep Sequencing of the Small RNA Transcriptome of Normal and Malignant Human B cells Identifies Hundreds of Novel...
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-22898 | biostudies-arrayexpress
ProteomicsBlood exposure induces global changes in gene expression and protein secretion of B. pertussis
This project was focused on transcriptome and secretome of pathogenic bacteria B. pertussis, which were cultivated on solid plates (charcoal agar) with/without blood and subsequently sub-cultured in liquid media. As a standard, Bordetella spp. strain are grown on agar plates supplemented with blood....
ORGANISM(S): Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2021-09-09 | PXD022760 | Pride
Blood Lfq ms Bordetella pertussis Virulence factors 
GenomicsGenetic Heterogeneity of Diffuse Large B Cell Lymphoma

We sequenced exomes of 94 DLBCL tumors and cell lines. 34 of the tumors had paired normal tissue. Our work elucidates commonly occurring gene-coding mutations in DLBCL.

phs000573.v1.p1 | EGA
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