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TranscriptomicsGenome-wide DNA methylation in CEBPA mutant and CEBPA silenced AML
Acute Myeloid Leukemia (AML) is a heterogeneous disease from the molecular and biological standpoints, and even patients with a specific gene expression profile may present clinical and molecular heterogeneity. We studied the epigenetic profiles of a cohort of patients that shared a common gene expr...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-14417 | biostudies-arrayexpress
TranscriptomicsBCL6 repression of EP300 provides a basis for rational combinatorial therapy in diffuse large B cell lymphomas.
The BCL6 transcriptional repressor is a critical oncogene in diffuse large B-cell lymphomas (DLBCL). The specific BCL6 inhibitor RI-BPI potently kills DLBCL cells. We find that RI-BPI induces a particular gene expression signature in DLBCL. In order to identify classes of drugs that might synergize ...
ORGANISM(S): Homo sapiens 
2010-09-21 | E-GEOD-24236 | biostudies-arrayexpress
TranscriptomicsCell of origin influences molecular and functional properties of murine induced pluripotent stem cells
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here, we show that iPSCs obtained from fibrobla...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-22827 | biostudies-arrayexpress
TranscriptomicsChemosensitization of DLBCL cells in vitro and in vivo by demethylating nucleoside analogues [methylation]
Silencing of genes that suppress the malignant phenotype by DNA methylation spurred an interest in the clinical use of epigenetic reprogramming agents. Single therapy is unlikely to be curative in the context of a heterogeneous disease such as Diffuse Large B cell Lymphomas (DLBCL). The combination ...
ORGANISM(S): Homo sapiens 
2012-07-29 | E-GEOD-31101 | biostudies-arrayexpress
TranscriptomicsMyelodysplastic syndrome marrow stroma shows widespread aberrant hypermethylation that is abrogated by treatment with DNMT inhibitors
The marrow microenvironment contributes to the pathogenesis of ineffective hematopoiesis in Myelodysplastic Syndromes (MDS). Since mutations and cytogenetic alterations are generally not present in marrow stromal cells, we hypothesized that epigenetic alterations may be responsible for altered strom...
ORGANISM(S): Homo sapiens 
2015-05-20 | E-GEOD-60233 | biostudies-arrayexpress
TranscriptomicsIntegrated Genetic and Epigenetic Analysis of Childhood ALL Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype [194 samples]
Acute lymphoblastic leukemia (ALL), the commonest childhood malignancy, is characterized by recurring gross and submicroscopic structural genetic alterations that contribute to leukemogenesis. Disordered epigenetic regulation is a hallmark of many tumors, and while analysis of DNA methylation of lim...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-44860 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma
Mantle Cell Lymphoma (MCL) is a mostly incurable malignancy arising from naïve B cells (NBC) in the mantle zone of lymph node follicles. We analyzed genome-wide methylation in MCL patients using the HELP (Hpa II tiny fragment Enrichment by Ligation mediated PCR) assay and found significant aberrancy...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-19243 | biostudies-arrayexpress
TranscriptomicsIntegrated Genetic and Epigenetic Analysis of Childhood ALL Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype [186 samples]
Acute lymphoblastic leukemia (ALL), the commonest childhood malignancy, is characterized by recurring gross and submicroscopic structural genetic alterations that contribute to leukemogenesis. Disordered epigenetic regulation is a hallmark of many tumors, and while analysis of DNA methylation of lim...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-38295 | biostudies-arrayexpress
TranscriptomicsChemosensitization of DLBCL cells in vitro and in vivo by demethylating nucleoside analogues
This SuperSeries is composed of the following subset Series: GSE28744: Chemosensitization of DLBCL cells in vitro and in vivo by demethylating nucleoside analogues [gene expression] GSE31101: Chemosensitization of DLBCL cells in vitro and in vivo by demethylating nucleoside analogues [methylation] R...
ORGANISM(S): Homo sapiens 
2012-07-29 | E-GEOD-31104 | biostudies-arrayexpress
TranscriptomicsHigh resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis
Differentiation of hematopoietic stem cells to red cells requires coordinated expression of numerous erythroid genes. To understand the regulatory mechanisms governing lineage commitment we conducted a high resolution methylomic and transcriptomic analysis of six major stages of human erythroid diff...
ORGANISM(S): Homo sapiens 
2013-02-05 | E-GEOD-44054 | biostudies-arrayexpress
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