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TranscriptomicsGenomic profiling of Richter-syndrome Chronic Lymphocytic Leukemia
Richter syndrome (RS) occurs in up to 15% of patients with chronic lymphocytic leukemia (CLL). While RS, usually represented by the histologic transformation to a diffuse large B-cell lymphoma (DLBCL), is associated with a very poor outcome, especially when clonally related to the pre-existing CLL, ...
ORGANISM(S): Homo sapiens 
2013-09-20 | E-GEOD-50252 | biostudies-arrayexpress
GenomicsMINCR is a MYC-induced lncRNA able to modulate MYC’s transcriptional network in Burkitt lymphoma cells
Despite the established role of the transcription factor MYC in cancer, little is known about the involvement of lncRNAs in mediating MYC’s function. Here we have intersected RNA-sequencing data from MYC-inducible cell lines, from a cohort of 91 mature B-cell lymphomas and from sorted germinal-cente...
EGAS00001001199 | EGA
TranscriptomicsGenome-wide gene expression analysis of Cirh1a heterozygote state on early embryo in mice
CIRHIN is a transcription co-factor, shows postive effect on Hiv-1 LTR enhancer element(NF-κB site); and Cirh1a null is preimplantation lethal, but highly expressed in the early mice embryo (E6.0-E12.5). We hypothesis that Cirh1a's effect on gene transcription of early embryo can be detected with ...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-51104 | biostudies-arrayexpress
TranscriptomicsSpecific miRNA Stabilization by Gld2-catalyzed Monoadenylation
miRNAs are small non-coding RNAs that inhibit translation and promote mRNA decay. The levels of mature miRNAs are the result of different rates of transcription, processing, and turnover. The non-canonical polymerase Gld2 has been implicated in the stabilization of miR-122 possibly by catalyzing 3’...
ORGANISM(S): Homo sapiens 
2013-02-23 | E-GEOD-41786 | biostudies-arrayexpress
GenomicsGenome-wide identification of distinct miRNA-mRNA target regulation pairs in Non-Hodgkin lymphomas: a report from the ICGC MMML-Seq consortium
We obtained miRNA profiles by miRnome sequencing from ICGC MMML-Seq patients diagnosed with Burkitt lymphoma, diffuse large B-cell lymphoma and follicular lymphoma and provide evidence of subtype-specific miRNA expression differences. We describe differentially expressed, mutated, edited and not pre...
EGAS00001001394 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-16-07-2015-15:45:02:488-51 - samples
Despite the established role of the transcription factor MYC in cancer, little is known about the impact of a new class of transcriptional regulators, the long non-coding RNAs (lncRNAs), on the way MYC is able to influence cellular transcriptome. To this aim we have intersected RNA-sequencing data f...
EGAD00001001441 | EGA
ProteomicsTargeting peptidyl-arginine deiminase 4 suppresses SARS-CoV-2 replication and modulates the inflammatory response
This project presents a comprehensive, quantitative proteomics and citrullinome profiling study designed to define how viral infection remodels host protein citrullination and related cellular pathways. The experimental design integrates in vitro and in vivo models of infection, including cultured h...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-01-30 | PXD072601 | Pride
Protein arginine deiminase Inflammation Covid Lung Padi4 
Genomicsena-DATASET-DKFZ-IBIOS-28-08-2015-09:49:06:632-229 - samples
RNA-sequencing data from teh hT-RPE-MycER cell line after MYC activation and after MINCR knock-down in conditions of MYC ON or OFF
EGAD00001001598 | EGA
GenomicsMMML associated cell line data
Data Access Committee EGAC00001000381
EGAC00001000381 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-16-09-2015-13:05:30:578-414 - samples
After overexpression and knockdown of both described novel miRs nmiR-1 and nmiR-2 in BL cell lines (SU-DHL4 for nmiR-1 and Raji for nmiR-2), we performed regular RNA-Seq (including Mock controls for all cell lines) to identify their direct and indirect downstream mRNA targets.
EGAD00001001612 | EGA
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