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TranscriptomicsExpression data of thermally eluted RNA from human primary fibroblasts with non-targeting or GLD4 siRNA treatment
In a screen for downregulated genes in poly(U) chromatography upon GLD4 knockdown, we identified carbohydrate metabolism genes were affected including a glucose transporter, GLUT1 human primary fibroblasts are treated with non-targeting siRNA or siGLD4. RNAs were subjected to poly(U) chromatography ...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-77747 | biostudies-arrayexpress
TranscriptomicsZMYM2/FGFR1, BCR/FGFR1 or BCR/ABL1 in human cord blood CD34+ cells reveals similar but distinct gene expression profiles
The 8p11 myeloproliferative syndrome (EMS), also referred to as the stem cell leukemia/lymphoma syndrome, is a chronic myeloproliferative disorder that rapidly progresses into an acute leukemia. Molecularly, EMS is characterized by fusion of various partner genes to the FGFR1 gene, resulting in cons...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-15811 | biostudies-arrayexpress
TranscriptomicsAnalysis of striatal transcriptome in transgenic mice overexpressing human wild-type alpha-synuclein
Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson’s disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic neurons, more extensive yet regionally selective neurodegeneration is observed in other syn...
ORGANISM(S): Mus musculus 
2012-02-11 | E-GEOD-35723 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neutrophils obtained after exposure endotoxin by bronchoscopic instillation reveals differential gene expression between air space and circulating neutrophils
Although the accumulation of neutrophils in the lungs and airways is common to many inflammatory lung diseases, including acute lung injury, the alterations that neutrophils undergo as they leave the peripheral circulation and migrate into the lungs have not been well characterized. Human volunteers...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2322 | biostudies-arrayexpress
TranscriptomicsMondoA is highly expressed in acute lymphoblastic leukemia and modulates metabolism, differentiation and survival
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted treatment of childhood ALL, we performed a comprehensive transcriptome analysis yielding a set of genes specifically overexpressed in ALL. Among them we identified MondoA - a transcripti...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-33967 | biostudies-arrayexpress
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