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TranscriptomicsIdentification and validation of NOL5A and RPS2 as potential therapeutic targtes in colorectal cancer
Identification and validation of NOL5A and RPS2 as potential therapeutic targets in colorectal cancer using a functional genomics approach. To identify potential therapeutic targets for colorectal cancer, we first assessed the functional and molecular consequences of RNAi mediated silencing of candi...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-15212 | biostudies-arrayexpress
ProteomicsYME1L1 KnockOut MEF Cells Whole Proteomics
Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remained enigmatic. We found that mtDNA-dependent immune signaling via the cGAS-STING pathway is under metabolic control and induced by cellular nucleotide deficien...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-27 | PXD018097 | Pride
Isg Yme1l1 Yme1l Mef cells 
TranscriptomicsThe rectal cancer microRNAome - a comprehensive comparative analysis of microRNA expression in rectal cancer and matched normal mucosa
Purpose: MicroRNAs play a prominent role in a variety of physiological and pathological biological processes, including cancer. For rectal cancers, only limited data are available on microRNA expression profiles, while the underlying genomic and transcriptomic aberrations have been firmly establishe...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-38389 | biostudies-arrayexpress
TranscriptomicsA 50-Gene Predictor of Recurrence as a Guide to Therapy in Early-Stage Colon Cancer.
Gene expression profiles reflect unique aspects of individual biologic phenotypes and may characterize the heterogeneity of solid tumors. Using previously-described methodologies that employ DNA microarray data, a 50-gene expression profile (metagene) that predicts risk of recurrence in early stage ...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-10402 | biostudies-arrayexpress
ProteomicsMitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7
Coenzyme Q (or ubiquinone) is a redox-active lipid, which serves as universal electron carrier in the mitochondrial respiratory chain and antioxidant in the plasma membrane limiting lipid peroxidation and ferroptosis. Mechanisms allowing cellular coenzyme Q distribution after synthesis within mitoch...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-11-12 | PXD033064 | Pride
Mitochondria Stard7 Coq 
TranscriptomicsSystems-wide RNAi analysis of CASP8AP2 / FLASH
We have used a combination of RNAi based functional and molecular genomic approaches to investigate in detail two proteins required for the survival of CRC cells. Set1 has 22 samples, 10 siNeg controls, 6 siRNA transfections for FLASH and NUP62 each. Set2 has 67 samples, siNeg controls at timepoint:...
ORGANISM(S): Homo sapiens 
2012-05-06 | E-GEOD-29405 | biostudies-arrayexpress
TranscriptomicsA Gene Expression Signature for Chemoradiosensitivity of Colorectal Cancer Cells
In this study, we use cancer cell lines to investigate the molecular differences between resistant and responsive colorectal cancer cells. Since the treatment of patients with locally advanced rectal cancers involves chemoradiotherapy (CT/RT), we specifically implemented an in vitro protocol that m...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-20298 | biostudies-arrayexpress
TranscriptomicsPatterns of somatic uniparental disomy identify driver tumor suppressor genes in colorectal cancer [Illumina]
The aim of this study is to establish an integrative profiling of recurrent UPDs/UPPs, CNAs and genome-wide methylation status in sporadic CRC. Our results indicate that regions showing high frequencies of UPDs/UPPs mostly coincide with regions typically involved in genomic losses such as chromosome...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-64112 | biostudies-arrayexpress
ProteomicsNerv. System Specific Yme1l KO (NYKO) Mice Retina Samples (30-31wks old)
Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remain enigmatic. We found that mtDNA-dependent immune signalling via the cGAS-STING pathway is under metabolic control and induced by cellular nucleotide deficienc...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-27 | PXD019849 | Pride
Retina Nyko 
TranscriptomicsGene Expression Profiling Reveals a Massive, Aneuploidy-Dependent Transcriptional Deregulation and Distinct Differences between Lymph Node–Negative and Lymph Node–Positive Colon Carcinomas
To characterize patterns of global transcriptional deregulation in primary colon carcinomas, we did gene expression profiling of 73 tumors [Unio Internationale Contra Cancrum stage II (n = 33) and stage III (n = 40)] using oligonucleotide microarrays. For 30 of the tumors, expression profiles were c...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-20970 | biostudies-arrayexpress
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