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Mitochondrial protein import through the outer and inner membranes is key to mitochondrial biogenesis. Recent studies have explored how cells respond when import is impaired by a variety of different insults. Here, we developed a mammalian import blocking system using dihydrofolate reductase (DHFR) ...
ORGANISM(S): Human 
2024-10-24 | MSV000096201 | MassIVE
Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remained enigmatic. We found that mtDNA-dependent immune signaling via the cGAS-STING pathway is under metabolic control and induced by cellular nucleotide deficien...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-27 | PXD018097 | Pride
Mitochondria are central metabolic hubs whose structure and function dynamically adapt to changing metabolic demands and environmental challenges. Metabolic reprogramming of mitochondria occurs during development, cell differentiation and in disease and is coupled to changes in mitochondrial mass an...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-21 | PXD011750 | Pride
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