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ProteomicsYME1L1 KO Hypoxia Proteome - Lipid signalling drives proteolytic rewiring of mitochondria by YME1L
Mitochondria are central metabolic hubs whose structure and function dynamically adapt to changing metabolic demands and environmental challenges. Metabolic reprogramming of mitochondria occurs during development, cell differentiation and in disease and is coupled to changes in mitochondrial mass an...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-21 | PXD011750 | Pride
Mefs Mouse Hela Yme1l1 Hypoxia 
ProteomicsYme1l substrate quantification under Leucine and Glutamine starvation as well as Torin treatment
Metabolic reprogramming of mitochondria occurs during development, cell differentiation and in cancer and is coupled to changes in mitochondrial mass and shape. Here, we demonstrate that the i-AAA protease YME1L rewires the proteome of pre-existing mitochondria in response to hypoxia or nutrient sta...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-21 | PXD014405 | Pride
Dia Mef cells Yme1l Lc-ms/ms 
GenomicsmTORC1 dependent lipid signalling drives acute proteolytic rewiring of mitochondria by YME1L
mTORC1 dependent lipid signalling drives acute proteolytic rewiring of mitochondria by YME1L
PRJNA552462 | ENA
UnknownLoss of Yme1L perturbates mitochondrial dynamics.
Not available
S-EPMC3920928 | biostudies-literature
TranscriptomicsmTORC1 dependent lipid signalling drives acute proteolytic rewiring of mitochondria by YME1L
Metabolic reprogramming of mitochondria occurs during development, cell differentiation and in disease and is coupled to changes in mitochondrial mass and shape. Here, we demonstrate that the i-AAA protease YME1L rewires the proteome of pre-existing mitochondria in response to hypoxia or nutrient st...
ORGANISM(S): Mus musculus 
2019-08-28 | GSE133753 | GEO
GenomicsMetabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L
Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L
PRJNA796583 | ENA
UnknownYME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.
Not available
S-EPMC4304733 | biostudies-literature
UnknownYME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions.
Not available
S-EPMC10946153 | biostudies-literature
TranscriptomicsMetabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L
The transition between quiescence and activation in neural stem and progenitor cells (NSPCs) is coupled to reversible changes in energy metabolism with key implications for life-long NSPC self-renewal and neurogenesis. How this metabolic plasticity is ensured between NSPC activity states is unclear....
ORGANISM(S): Mus musculus 
2022-01-19 | GSE193551 | GEO
ProteomicsNerv. System Specific Yme1l KO (NYKO) Mice Retina Samples (30-31wks old)
Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remain enigmatic. We found that mtDNA-dependent immune signalling via the cGAS-STING pathway is under metabolic control and induced by cellular nucleotide deficienc...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-27 | PXD019849 | Pride
Retina Nyko 
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