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ProteomicsSystematic Workflow Optimization for Ultra-Sensitive Targeted Immunopeptidomics
Epitope detection sensitivity remains a primary bottleneck in mass spectrometry (MS)-based immunopeptidomics, as conventional discovery-based workflows such as data-dependent (DDA) and data-independent acquisition (DIA) frequently lack the sensitivity required to detect ultra-low abundant targets. W...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD074199 | Pride
Targeted Immunopeptidomics Hpv Prm Cancer 
ProteomicsoptiPRM: A targeted immunopeptidomics LC-MS workflow with ultra-high sensitivity for the detection of mutation-derived tumor neoepitopes from limited input material
Personalized cancer immunotherapies such as vaccines and T cell receptor (TCR)-transgenic T cells rely on the presentation of tumor-specific peptides by human leukocyte antigen (HLA) class I molecules to cytotoxic T cells. Such neoepitopes can for example arise from somatic mutations and their ident...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD043542 | Pride
Immunopeptidomics Prm Lc-ms Targeted ms 
ProteomicsA therapeutically tractable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer
Small cell lung cancer (SCLC) is among the deadliest cancers with excessive somatic alterations, expectedly resulting in immunogenic epitopes. However, patient benefit from immunotherapy is limited. We found abundant frameshift mutations in SCLC, regarded as highly immunogenic, counterbalanced by a ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD066995 | Pride
Nonsense-mediated decay  lung cancer  sclc  immunopeptidomics  neoepitope  data-independent aquisitiona  faims  parallel reaction monitoring 
ProteomicsSystematic Workflow Optimization for Ultra-Sensitive Targeted Immunopeptidomics
Epitope detection sensitivity remains a primary bottleneck in mass spectrometry (MS)-based immunopeptidomics, as conventional discovery-based workflows such as data-dependent (DDA) and data-independent acquisition (DIA) frequently lack the sensitivity required to detect ultra-low abundant targets. W...
ORGANISM(S): Homo Sapiens Human Papillomavirus 16 
2026-08-27 | PXD074373 | panorama
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