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TranscriptomicsComparative genomics reveals new molecular targets for accelerated strain improvement of rifamycin B-producing strains
In the present study, we have used a genomic approach to understand how the classical mutate-and-screen method actually generated an improved rifamycin B producer. Compared with the reference strains Amycolatopsis mediterranei S699 (rifamycin B producer) and U32 (rifamycin SV producer), a total of 2...
ORGANISM(S): Amycolatopsis mediterranei S699 
2014-08-26 | E-GEOD-51015 | biostudies-arrayexpress
TranscriptomicsRifamycin O as a Novel CRBN Ligand for Targeted Degradation of IKZF1/3 Proteins in Hematopoietic Malignancies
We found that Rifamycin O could effectively suppressed the hematologic tumors growth in vitro and in vivo. The antitumor effect of Rifamycin O is first identified so far.
ORGANISM(S): Homo sapiens 
2026-05-01 | GSE297439 | GEO
TranscriptomicsComparative genomics reveals new molecular targets for accelerated strain improvement of rifamycin B-producing strains
In the present study, we have used a genomic approach to understand how the classical mutate-and-screen method actually generated an improved rifamycin B producer. Compared with the reference strains Amycolatopsis mediterranei S699 (rifamycin B producer) and U32 (rifamycin SV producer), a total of 2...
ORGANISM(S): Amycolatopsis mediterranei S699 
2014-08-26 | GSE51015 | GEO
GenomicsRifamycin O as a Novel CRBN Ligand for Targeted Degradation of IKZF1/3 Proteins in Hematopoietic Malignancies
Rifamycin O as a Novel CRBN Ligand for Targeted Degradation of IKZF1/3 Proteins in Hematopoietic Malignancies
PRJNA1263846 | ENA
UnknownCharacterization of the Rifamycin-Degrading Monooxygenase From Rifamycin Producers Implicating Its Involvement in Saliniketal Biosynthesis.
Not available
S-EPMC7283461 | biostudies-literature
ProteomicsComparative gene expression profiling of mutants of Amycolatopsis mediterranei S699
The project aims to unveil the mechanism of rifamycin and its analog production by wild type A. mediterranei S699 and mutant A. mediterranei DCO#34 known to produce 24-desmethylrifamycin B at two time points. Stain that donot produce this molecule is taken as the negative control in the study.
ORGANISM(S): Amycolatopsis mediterranei S699 
2021-03-11 | PXD016416 | Pride
24-desmethylrifamycin b Amycolatopsis 42h and 96h Production mechanism Rifamycin 
UnknownDeciphering the late steps of rifamycin biosynthesis.
Not available
S-EPMC6002545 | biostudies-literature
UnknownGenome Mining Reveals Rifamycin Biosynthesis in a Taklamakan Desert Actinomycete.
Not available
S-EPMC12114206 | biostudies-literature
UnknownRifamycin O, An Alternative Anti-Mycobacterium abscessus Agent.
Not available
S-EPMC7181020 | biostudies-literature
GenomicsChlamydia suis
Rifampicin/Rifamycin resistant Chlamydia suis strains
PRJNA668464 | ENA
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